正念训练对一氧化二氮成瘾患者临床疗效的影响

Effects of mindfulness training on clinical efficacy in patients with nitrous oxide addiction

目的研究正念训练对一氧化二氮(笑气)成瘾患者的临床效果。方法选择2019年6月至2020年6月期间于北京高新医院收治的笑气成瘾患者66例,采用随机数字表法将患者分为试验组(n=33)和对照组(n=33)。对照组患者进行太极拳训练及体能训练,试验组在太极拳训练及体能训练的基础上增加基于正念的干预训练,共进行8周。比较两组患者入院时及治疗8周后症状自评量表(symptom check list 90,SCL-90)评分及视觉模拟标尺(visual analog scales,VAS)渴求分数。采用SPSS 22.0软件进行统计分析,采用独立样本t检验,配对样本t检验比较组间和组内差异。结果(1)治疗前两组SCL-90除抑郁[(2.45±0.86)分,(2.03±0.46)分](t=2.474,P<0.05)因子外,其他各因子分数均差异无统计学意义(均P>0.05);治疗后试验组SCL-90躯体化[(1.38±0.35)分,(1.68±0.34)分](t=-3.656,P<0.05)、恐怖[(1.49±0.37)分,(1.81±0.30)分](t=-3.993,P<0.05)、偏执[(1.50±0.47)分,(1.88±0.31)分](t=-3.898,P<0.05)、精神病性[(1.34±0.54)分,(1.55±0.27)分](t=-3.094,P<0.05)因子分数均显著低于对照组。(2)治疗前两组VAS渴求分数差异无统计学意义(t=0.857,P=0.395);治疗后试验组VAS渴求分数比对照组低,差异具有统计学意义(t=27.427,P<0.05)。结论正念训练干预能够有效改善一氧化二氮成瘾患者的临床症状,值得临床推广应用。

Objective To study the effect of mindfulness-based training intervention on clinical efficacy in patients with nitrous oxide(laughing gas)addiction.Methods From June 2019 to June 2020,sixty-six patients with nitrous oxide addiction in Beijing Gaoxin Hospital were selected and randomly divided into experimental group(n=33)and control group(n=33).The control group received Taijiquan training and physical training,while the experimental group added mindfulness-based training intervention on the basis of Taijiquan training and physical training.Symptom checklist 90(SCL-90)scores and visual analog scales(VAS)craving scores were compared between the two groups at admission and 8 weeks after treatment.SPSS 22.0 software was used for statistical analysis.Independent sample t test and paired sample t test were used to compare the differences between groups and within groups.Results(1)Before treatment,there were no significant differences in subscale scores of SCL-90 between the two groups except for depression factor((2.45±0.86),(2.03±0.46),t=2.474,P<0.05).After treatment,the subscale scores of somatization((1.38±0.35),(1.68±0.34),t=-3.656,P<0.05),phobic anxiety((1.49±0.37),(1.81±0.30),t=-3.993,P<0.05),paranoid ideation((1.50±0.47),(1.88±0.31),t=-3.898,P<0.05)and psychotism((1.34±0.54),(1.55±0.27),t=-3.094,P<0.05)of SCL-90 in the experimental group were significantly lower than those in the control group.(2)Before treatment,there was no significant difference in VAS craving score between the two groups(t=0.857,P=0.395).After treatment,the score of VAS in the experimental group was significantly lower than that in the control group(t=27.427,P<0.05).Conclusion Mindfulness training intervention can effectively improve the clinical symptoms of patients with nitrous oxide addiction,which is worthy of clinical application.