1h集束化干预对脓毒症患者功能改善及预后的影响研究

Study on the effect of 1H cluster intervention on the functional im-provement and prognosis of sepsis patients

目的研究1h集束化干预对脓毒症患者功能改善及预后的影响.方法以华中科技大学同济医学院附属梨园医院2018年1月—2019年12月治疗的120例脓毒症老年患者作为研究对象,本院于2019年正式实施1 h集束化干预措施,本研究所有病例均由随机抽样取得,其中以2018年治疗患者60例作为对照组,以2019年治疗患者60例作为观察组,比较两组患者的功能改善、后续治疗情况以及预后之间的差异.结果经过治疗后,两组患者的中心静脉压、中心静脉血氧饱和度、平均动脉压、尿量均显著升高,血肌酐水平、心率显著降低,且观察组患者的中心静脉压、中心静脉血氧饱和度、平均动脉压、尿量显著高于对照组,血肌酐水平、心率显著低于对照组,差异存在统计学意义(P<0.05);观察组患者的复苏后的血管活性药物的应用、再次复苏的次数、激素替代治疗率显著低于对照组,观察组患者的机械通气时间、ICU住院时间、28d病死率显著低于对照组.结论脓毒症患者采取1h集束化干预,患者的病死率以及住院时间显著下降,功能改善较好,建议临床推广.

Objective To study the effect of one hour cluster intervention on the function improvement and prognosis of sepsis patients.Methods Taking 120 elderly patients with sepsis treated in our hospital in January 2018 and December 2019 as fhe research object,In 2019,our hospital formally implemented one hour cluster intervention measures.All cases in this study were randomly sampled.Among them,60 patients were treated in 2018 as the control group and 60 patients in 2019 as the observation group.The differences between the two groups in function improvement,follow-up treatment and prognosis were compared.Results After treatment,the central venous pressure,the central venous oxygen saturation,the average arterial pressure and the urine volume of the two groups were significantly increased,the blood creatinine level and the heart rate were significantly reduced,and the central venous pressure,the central venous oxygen saturation,the average arterial pressure and the urine volume of the observation group were significantly higher than those of the control group,and the blood creatinine level and the heart rate were significantly lower than those of the control group Significance(P<0.05);the application of vasoactive drugs,the times of resuscitation and the rate of hormone replacement therapy in the observation group were significantly lower than those in the control group,while the mechanical ventilation time,ICU stay time and 28 day mortality in the observation group were significantly lower than those in the control group.Conclusion The mortality and hospitalization time of sepsis patients were significantly reduced and the function of sepsis patients was improved after one hour of cluster intervention.It is suggested that the clinical application should be popularized.