sd-LDL在非乙醇性脂肪性肝病中的应用价值

VALUE OF SMALL DENSE LOW-DENSITY LIPOPROTEIN IN NONALCOHOLIC FATTY LIVER DISEASE

目的探讨小而密低密度脂蛋白(sd-LDL)在非乙醇性脂肪性肝病中的应用价值。方法回顾性纳入2018年4月—2019年5月就诊于复旦大学附属华山医院门诊的非乙醇性脂肪性肝病病人87例,以87例健康体检者作为对照。收集所有研究对象的一般临床资料、血脂水平及FibroTouch肝脏脂肪衰减值。根据肝脏脂肪衰减度将非乙醇性脂肪性肝病病人分为轻度、中度和重度组,比较各组脂肪肝病人的临床资料,并分析血清sd-LDL水平与肝脏脂肪衰减度相关性。结果与健康对照相比,非乙醇性脂肪性肝病病人的体质量指数(BMI)、空腹血糖、三酰甘油、胆固醇、低密度脂蛋白(LDL)、sd-LDL及肝脏脂肪衰减度显著升高(Z=1206~3098,P<0.05)。轻度、中度、重度组脂肪肝病人的sd-LDL水平比较,差异具有显著性(H=15.2,P<0.01)。血清sd-LDL水平与肝脏脂肪衰减度呈正相关(r=0.37,P<0.01)。结论血清sd-LDL与肝脏脂肪化程度相关,可作为一种新型非乙醇性脂肪性肝病的生物学标志物,有助于临床评估及监测病情。

Objective To investigate the value of small dense low-density lipoprotein(sd-LDL)in nonalcoholic fatty liver disease(NAFLD).Methods A retrospective analysis was performed for 87 patients with NAFLD who attended the outpatient service of Huashan Hospital,Fudan University,from April 2018 to May 2019,and 87 individuals who underwent physical examination were enrolled as control.General clinical data,blood lipid levels,and FibroTouch controlled attenuation parameter(CAP)were collected from all subjects.According to CAP,the patients with NAFLD were divided into mild,moderate,and severe groups,and clinical data were compared between groups to analyze the correlation between serum sd-LDL level and CAP.Results Compared with the healthy control group,the NAFLD group had significantly higher body mass index,fasting blood glucose,triglyceride,cholesterol,low-density lipoprotein,and sd-LDL(Z=1206-3098,P<0.05).There was a significant difference in the level of sd-LDL between the mild,moderate,and severe groups(H=15.2,P<0.01).Serum sd-LDL level was positively correlated with CAP(r=0.37,P<0.01).Conclusion Serum sd-LDL is associated with the severity of NAFLD,and as a promising biomarker for NAFLD,it can help with clinical evaluation and monitoring of disease condition.