普萘洛尔联合垂体后叶素急救肝硬化并上消化道出血临床疗效及安全性分析

Analysis of clinical efficacy and safety of propranolol combined with pituitrin in the emergency treatment of liver cirrhosis with upper gastrointestinal bleeding

目的分析普萘洛尔联合垂体后叶素急救肝硬化并上消化道出血的应用效果。方法选取2016年1月至2019年12月本中心转送院内急救的肝硬化并上消化道出血患者50例,按照随机数字表法分为对照组和研究组,每组各25例。对照组给予垂体后叶素急救,研究组给予普萘洛尔联合垂体后叶素急救,比较两组临床疗效及安全性。结果研究组TBIL为(25.02±3.35)μmol/L,ALT为(37.68±9.68)U/L,低于对照组的(27.35±2.65)μmol/L、(51.57±9.64)U/L,差异有统计学意义(P<0.05);研究组ALB为(37.79±4.25)g/L,高于对照组的(34.68±4.36)g/L,差异有统计学意义(P<0.05)。研究组急救总有效率为96.00%,高于对照组的72.00%,差异有统计学意义(P<0.05)。研究组不良反应总发生率为8.00%,低于对照组的32.00%,差异有统计学意义(P<0.05)。结论普萘洛尔联合垂体后叶素急救肝硬化并上消化道出血患者,能够显著提升其肝功能、降低不良反应总发生率,急救疗效显著,具有推广价值。

Objective To analyze the application effect of propranolol combined with pituitrin in the emergency treatment of liver cirrhosis and upper gastrointestinal bleeding.Methods A total of 50 patients with liver cirrhosis and upper gastrointestinal hemorrhage transferred to first aid in hospital by our center from January 2016 to December 2019 were selected as the study objects,they were divided into the control group and the study group by random number table method,with 25 cases in each group.The control group was treated with pituitrin,and the study group was treated with propranolol combined with pituitrin.The clinical effects and safety of the two groups were compared.Results The TBIL(25.02±3.35)μmol/L and ALT(37.68±9.68)U/L of the study group were statistically significantly lower than(27.35±2.65)μmol/L、(51.57±9.64)U/L of the control group(P<0.05).The ALB of the study group(37.79±4.25)g/L was statistically significantly higher than(34.68±4.36)g/L of the control group(P<0.05).The total effective rate of emergency treatment in the study group was 96.00%,which was statistically significantly higher than 72.00%of the control group(P<0.05).The total incidence of adverse reactions in the study group(8.00%)was statistically significantly lower than 32.00%in the control group(P<0.05).Conclusion The treatment of propranolol combined with pituitrin in patients with liver cirrhosis and upper gastrointestinal bleeding can significantly improve their liver function,reduce the total incidence of adverse reactions and has a significant treatment effect,which has promotion value.