激素受体阳性乳腺癌患者辅助化疗同时卵巢抑制治疗对患者预后的影响研究

Effect of adjuvant chemotherapy and ovarian suppression therapy on the prognosis of patients with hormone receptor-positive breast cancer

目的探讨激素受体阳性乳腺癌患者辅助化疗同时卵巢抑制治疗对患者预后的影响。方法选取2011年9月至2014年2月在我院进行治疗的126例激素受体阳性乳腺癌患者,将患者随机分为常规组及研究组,常规组患者行改良根治术、腋窝淋巴结清扫术及CEF辅助化疗,研究组患者在常规治疗基础上加用卵巢抑制剂,比较两组患者治疗效果、生活质量、卵巢功能恢复情况及预后情况。结果研究组患者治疗有效率及疾病控制率分别为52.38%及82.54%,均显著高于常规组(P<0.05),且化疗后,研究组患者生活质量评分为(87.18±6.41)分,显著高于常规组(P<0.05),同时,研究组患者闭经时间及月经恢复正常时间分别为(2.05±0.59)个月及(4.76±1.21)个月,均显著短于常规组(P<0.05),而月经复潮率为88.89%,显著高于常规组(P<0.05),另外,治疗后5年,研究组中无症状患者比例为79.37%,显著高于常规组的47.62%(P<0.05)。结论在激素受体阳性乳腺癌患者辅助化疗同时进行卵巢抑制治疗,能够有效提高治疗效果,且对促进患者卵巢功能的恢复、生活质量的提高及改善预后程度等方面具有重要意义,值得推广。

Objective To explore the effect of adjuvant chemotherapy and ovarian suppression therapy on the prognosis of patients with hormone receptor-positive breast cancer.Methods A total of 126 hormone receptor-positive breast cancer patients who were treated in our hospital from September 2011 to February 2014 were selected.The patients were randomly divided into the routine group and the study group.Patients in the routine group were treated with modified radical surgery,axillary lymph node dissection surgery,and CEF adjuvant chemotherapy.The patients in the study group were added with ovarian inhibitors based on conventional treatment.The treatment effect,quality of life,ovarian function recovery,and prognosis of the two groups were compared.Results The treatment effective rate and disease control rate of the study group were 52.38%and 82.54%,significantly higher than those of the conventional group(P<0.05).After chemotherapy,the quality of life score of the study group was(87.18±6.41)points,which was significantly higher than that of the conventional group(P<0.05).At the same time,the time of amenorrhea and menstruation returning to normal in the study group were(2.05±0.59)months and(4.76±1.21)months,respectively,which were significantly shorter than those of the conventional group(P<0.05).The menstrual regain rate of the study group was 88.89%,which was significantly higher than that of the conventional group(P<0.05).In addition,five years after treatment,the proportion of asymptomatic patients in the study group was 79.37%,which was significantly higher than 47.62%of the conventional group(P<0.05).Conclusion Adjuvant chemotherapy for hormone receptor-positive breast cancer patients with ovarian suppression therapy can effectively improve the therapeutic effect,and has important significance in promoting the recovery of ovarian function,improving the quality of life,and improving the prognosis of patients.It is worthy of promotion.