细胞免疫功能指标与新型冠状病毒肺炎患者病情的相关性

Correlation Between the Indexes of Cellular Immune Function and the Condition of Patients with Corona Virus Disease 2019

目的分析细胞免疫功能指标与新型冠状病毒肺炎(COVID-19)患者病情的相关性。方法收集2020年1月22日至3月9日河南省人民医院收治的51例COVID-19患者的临床资料。将普通型患者纳入对照组(23例),将重型或危重型患者纳入观察组(28例)。比较两组年龄、性别、合并基础疾病和入院时外周血白细胞计数(WBC)、中性粒细胞计数(NEU)、单核细胞计数(MONO)、总淋巴细胞计数(LYM)、C反应蛋白(CRP)、T淋巴细胞计数、NK细胞计数、B细胞计数、CD4^(+)T淋巴细胞计数、CD4^(+)T淋巴细胞比率、CD8^(+)T淋巴细胞计数、CD8^(+)T淋巴细胞比率、CD3^(+)T淋巴细胞比率、CD4^(+)/CD8^(+)T淋巴细胞比值、CD19^(+)细胞比率、CD3^(-)CD16^(+)CD56^(+)细胞比率。结果与对照组比较,观察组年龄较大,合并基础疾病占比、WBC、NEU、CD4^(+)/CD8^(+)T淋巴细胞比值较高,CD8^(+)T淋巴细胞比率较低(P<0.05)。未合并基础疾病和较高的CD8^(+)T淋巴细胞比率为重症或危重症COVID-19发生的保护因素,而较高的CD4^(+)/CD8^(+)T淋巴细胞比值为重症或危重症COVID-19发生的危险因素(P<0.05)。结论合并基础疾病、CD8^(+)T淋巴细胞比率、CD4^(+)/CD8^(+)T淋巴细胞比值是重症或危重症COVID-19发生的影响因素。

Objective To analyze the correlation between the indexes of cellular immune function and the condition of patients with corona virus disease 2019(COVID-19).Methods Clinical data of 51 patients with COVID-19 admitted to Henan Provincial People’s Hospital from January 22 to March 9,2020 were collected.Twenty-three patients with common type were included into control group and 28 patients with severe or critical type were included into observation group.The age,sex,basic diseases and white blood cell count(WBC),neutrophil count(NEU),monocyte count(MONO),total lymphocyte count(LYM),C reactive protein(CRP),T-lymphocyte count,NK cell count,B cell count,CD4^(+)T lymphocyte count,CD4^(+)T lymphocyte percentage,CD8^(+)T lymphocyte count,CD8^(+)T lymphocyte percentage,CD3^(+)T lymphocyte percentage,CD4^(+)/CD8^(+)T lymphocyte ratio,CD19^(+)cell percentage and CD3^(-)CD16^(+)CD56^(+)cell percentage in the peripheral blood at admission were compared between the two groups.Results Compared with control group,the age was older,and the proportion of combined basic diseases and the levels of WBC,NEU and CD4^(+)/CD8^(+)T lymphocyte ratio were higher in observation group,while CD8^(+)T lymphocyte percentage was lower in observation group(P<0.05).Uncomplicated basic disease and higher CD8^(+)T lymphocyte percentage were the protective factors for the occurrence of severe or critical COVID-19,while higher CD4^(+)/CD8^(+)T lymphocyte ratio was the risk factor for the occurrence of severe or critical COVID-19(P<0.05).Conclusion Combined with basic diseases,CD8^(+)T lymphocyte percentage and CD4^(+)/CD8^(+)T lymphocyte ratio are the influencing factors for the occurrence of severe or critical COVID-19.