硫代硫酸钠治疗尿毒症血液透析患者皮肤瘙痒疗效观察

Effect of Sodium Thiosulfate on Skin Pruritus in Uremic Hemodialysis Patients

目的探讨硫代硫酸钠治疗尿毒症血液透析患者皮肤瘙痒疗效。方法选取2020年4月至2020年10月我院收治的56例血液透析治疗尿毒症皮肤瘙痒患者进行随机分组,对照组针对皮肤瘙痒情况予以常规治疗,研究组在对照组基础上加用硫代硫酸钠。记录两组治疗前后皮肤瘙痒积分、实验室指标、睡眠质量及生活质量变化情况。结果两组治疗前瘙痒评分对比P>0.05;治疗后研究组治疗后瘙痒评分优于对照组(P<0.05);两组治疗前ALB、P、Ca、Scr、BUN、PTH等指标对比均P>0.05,治疗后研究组ALB、P、Ca、Scr、BUN、PTH水平低于对照组(P<0.05);两组治疗前PSQI、WHOQOL-100量表评分对比均P>0.05,治疗后研究组PSQI、WHOQOL-100量表评分情况优于对照组(P<0.05)。结论硫代硫酸钠治疗尿毒症血液透析患者皮肤瘙痒具有良好的效果。

Objective To investigate the efficacy of sodium thiosulfate in the treatment of skin pruritus in uremic hemodialysis patients.Methods 56 cases of uremic pruritus treated by hemodialysis from April 2020 to October 2020 were randomly divided into two groups.The Control Group received routine treatment according to the condition of pruritus,the study group added Sodium thiosulfate to the control group.The score of Skin Pruritus,laboratory index,sleep quality and quality of life were recorded before and after treatment.Results The pruritus score of the two groups before treatment was P>0.05,after treatment,the pruritus score of the study group was better than that of the control group(P<0.05).The ALB,P,CA,SCR,bun,PTH and other indicators of the two groups before treatment were all P>0.05.After treatment,the levels of ALB,P,CA,SCR,bun,PTH in the study group were lower than those in the control group(P<0.05).The scores of PSQI and WHOQOL-100 in the two groups before treatment were all P>0.05,and after treatment,the scores of PSQI and WHOQOL-100 in the two groups were all P>0.05.The scores of PSQI and WHOQOL-100 in the study group were better than those in the control group(P<0.05).Conclusion Sodium thiosulfate is effective in the treatment of pruritus in uremic hemodialysis patients.