巨噬细胞移动抑制因子与心房颤动的研究进展

Research progress of macrophage migration inhibitory factor and atrial fibrillation

巨噬细胞移动抑制因子(MIF)是一种多效性炎性细胞因子,在心房颤动(AF)患者中高表达。心房电重构、结构重构、氧化应激、炎性反应等在心房颤动的发病机制中起重要作用,MIF可能与心房颤动的众多因素相关,参与了心房颤动的各个过程。文章对MIF在不同方面促进心房颤动的发生发展及其抑制剂的治疗前景的治疗前景进行综述,推测靶向MIF的药物可能成为心房颤动治疗的新靶标。

Macrophage migration inhibitory factor(MIF)is a pleiotropic inflammatory cytokine,which is highly expressed in patients with atrial fibrillation(AF).Atrial electrical remodeling,structural remodeling,oxidative stress,inflammatory response,etc.play an important role in the pathogenesis of atrial fibrillation.MIF may be related to many factors of atrial fibrillation and participate in various processes of atrial fibrillation.This article reviews the different aspects of MIF promoting the occurrence and development of atrial fibrillation and its inhibitors,and speculates that drugs targeting MIF may become a new target for the treatment of atrial fibrillation.