光声成像在肿瘤诊断和治疗中的研究进展

Research progress of photoacoustic imaging in tumor

癌症一直是困扰人类的一大难题,常规成像方法在肿瘤的诊断上存在一定的局限。光声成像作为目前医学影像研究的新热点,相比于常规影像方法,它可以利用内源性对比剂如黑色素和血红蛋白,实时且无创地监测与肿瘤血管生成相关物质的浓度,或者通过分子靶向性外源性造影剂与抗体或多肽结合,提供关于肿瘤结构及其分子信息,从而实现形态及功能成像。近年来,光声成像为癌症的早期诊断、肿瘤血管生成的研究、肿瘤微环境的探测,以及癌症进展和治疗反应的监测做出了有价值的贡献。根据光声成像在肿瘤成像上展示出的独特优势,本文就此种医学成像方法在癌症诊断、分期和治疗指导中的应用进展进行综述。

Cancer has always been a difficult problem for human beings,and conventional imaging methods have some limitations in the diagnosis of tumors.Photoacoustic imaging(PAI)is one of flourishing fields of medical imaging methods.Compared with conventional radiology techniques,it can use endogenous or exogenous contrast agents such as melanin and hemoglobin to monitor the concentration of subst-ances related to tumor angiogenesis in real time and noninvasively,or through the molecular targeting exogenous contrast agent to combine with antibodies or peptides to provide information about the structure of the tumor and its molecular information,so as to achieve morphological and functional imaging.In recent years,PAI has made a valuable contribution to the early diagnosis of cancer,the study of tumor angiogenesis,the detection of tumor microenvironment,and the monitoring of cancer progression and treatment response.According to the unique advantages of PAI in tumor imaging.The application progress of photoacoustic imaging in tumor diagnosis,management and treatment guidance were reviewed.