摘要
肾脏的基因治疗近些年研究较多并取得了一定的进展,其研究热点主要集中在腺相关病毒。本文概述了腺相关病毒在基因转导的研究进展,综述了靶向肾小管的基因转导的不同途径和基因载体,探讨了腺相关病毒靶向肾小管的基因转导策略及存在的问题。
Renal gene therapy has been studied in recent years,and some progress has been made.The research focus was mainly on adeno-associated virus.This article summarized the research progress of adeno-associated virus in gene transduction,reviewed the different transduction pathways and gene vectors of gene transduction targeting the renal tubules,and discussed the gene transduction strategies and the existing problems in adeno-associated virus gene transduction targeting the renal tubules.
作者
马强
敖强国
张雅宾
程庆砾
Ma Qiang;Ao Qiangguo;Zhang Yabin;Cheng Qingli(Department of Nephrology and National Institute of Geriatrics, Second Medical Center of General Hospital of Chinese PLA, Beijing 100853, China)
出处
《中华肾病研究电子杂志》
2021年第2期113-116,共4页
Chinese Journal of Kidney Disease Investigation(Electronic Edition)
关键词
腺相关病毒
肾小管
基因转导
Adeno-associated virus
Renal tubule
Gene transduction