摘要
目的分析紫杉醇注射剂用药情况及其发生不良反应的影响因素,以期指导临床合理用药。方法选择274例接受紫杉醇治疗的患者为试验对象,对其均进行临床资料分析、调查,随后使用Logistic回归分析法探讨出现不良反应的危险因素。结果177例出现不良反应的患者大部分严重状态处于中重度,其中34.46%为头颈部癌,最常见的累及器官/系统为血液系统,临床表现为贫血、骨髓抑制。发生不良反应组的男性、年龄>60岁、肿瘤科、超说明书用药、预防用药、联合铂类药物患者占比高于未发生不良反应组(P<0.05)。Logistic回归分析结果显示,年龄、科室、超说明书用药、预防用药是导致患者出现不良反应的危险因素(P<0.05)。结论紫杉醇注射液引起不良反应的概率较高,且诱发因素较多,为此需针对以上因素进行有效预防,从而保证临床用药的安全性。
Objective To analyze of the medication of paclitaxel injection and its influencing factors of adverse reactions,in order to guide clinical rational drug use.Methods A total of 274 patient received paclitaxel treatment were selected as the test objects,and the clinical data of patients were analyzed and investigated,and then the risk factors of adverse reactions were discussed by Logistic regression analysis method.Results Most of the 177 patients with adverse reactions were in a moderate to severe state,of which 34.46%were head and neck cancer.The most common involved organ/system was the blood system,and the clinical manifestations were anemia and bone marrow suppression.The proportion of patients with male,age>60 years,oncology department,off-label medication,prophylactic medication and combined platinum drugs in the adverse reactions group were higher than those in the non-adverse reactions group(P<0.05).Logistic regression analysis results showed that age,department,off-label medication and prophylactic medication were the risk factors of adverse reactions(P<0.05).Conclusion Paclitaxel injection has a higher incidence of adverse reactions and many inducing factors.Therefore,the above factors should be effectively prevented to ensure the safety of clinical medication.
作者
梁瑾
宁美丽
LIANG Jin;NING Meili(Xianyang Central Hospital,Xianyang 712000,China)
出处
《临床医学研究与实践》
2021年第14期26-28,共3页
Clinical Research and Practice
关键词
紫杉醇
不良反应
危险因素
paclitaxel
adverse reactions
risk factors