体外培育牛黄辅助治疗鼻咽癌合并肺部感染的疗效观察

Efficacy of Calculus Bovis Cultured in vitro in the Adjuvant Treatment of Nasopharyngeal Carcinoma Complicated with Pulmonary Infection

目的:探讨体外培育牛黄辅助治疗鼻咽癌合并肺部感染的疗效。方法:选取2018年2月至2020年10月重庆大学附属肿瘤医院收治的鼻咽癌合并肺部感染患者180例,以随机数字表法分为研究组和对照组,每组90例。两组患者均给予注射用哌拉西林钠他唑巴坦钠治疗,研究组患者加用体外培育牛黄治疗。观察两组患者的临床疗效、咳嗽停止时间、退热时间、抗菌药物使用时间、免疫功能指标及不良反应发生情况。结果:研究组患者的总有效率为85.56%(77/90),明显优于对照组的56.67%(51/90),差异有统计学意义(P<0.05)。研究组患者咳嗽停止时间、退热时间及抗菌药物使用时间明显短于对照组,差异均有统计学意义(P<0.01)。治疗后,研究组患者免疫功能指标CD4^(+)、CD4^(+)/CD8^(+)水平明显高于对照组,CD8^(+)水平明显低于对照组,差异均有统计学意义(P<0.05)。研究组患者恶心的发生率明显低于对照组,差异有统计学意义(P<0.05);两组患者血清氨基转移酶升高、腹泻和皮疹的发生率比较,差异均无统计学意义(P>0.05)。结论:体外培育牛黄辅助治疗鼻咽癌合并肺部感染效果较好,优于单用注射用哌拉西林钠他唑巴坦钠治疗。

OBJECTIVE:To probe into the efficacy of calculus bovis cultured in vitro in the adjuvant treatment of nasopharyngeal carcinoma complicated with pulmonary infection.METHODS:A total of 180 patients with nasopharyngeal carcinoma complicated with pulmonary infection admitted into Chongqing University Cancer Hospital from Feb.2018 to Oct.2020 were extracted to be divided into the study group and the control group,with 90 cases in each group.Both groups were treated with piperacillin sodium and tazobactam sodium for injection via the random number table,while the study group received bovis cultured in vitro.Clinical efficacy,disappearance time of cough and fever,application time of antibiotics,immune function indicators and occurrence of adverse drug reactions of two groups were observed.RESULTS:The total effective rate of the study group was 85.56%(77/90),significantly higher than that of the control group 56.67%(51/90),the difference was statistically significant(P<0.05).The disappearance time of cough and fever,application time of antibiotics in the study group were shorter than those in the control group,with statistically significant difference(P<0.01).After treatment,the immune function indicators such as CD4^(+)and CD4^(+)/CD8^(+)of the study group were significantly higher than those of the control group,and CD8^(+)was significantly lower than that of the control group,and the differences were statistically significant(P<0.05).The incidence of nausea in the study group was significantly lower than that in the control group,and the difference was statistically significant(P<0.05).There was no significant difference in the incidence of elevated serum aminotransferase,diarrhea and skin rash between two groups(P>0.05).CONCLUSIONS:The efficacy of calculus bovis cultured in vitro in the adjuvant treatment of nasopharyngeal carcinoma complicated with pulmonary infection is significant,which is better than piperacillin sodium and tazobactam sodium for injection alone.