羟基喜树碱药物递送系统抗肿瘤研究进展

Research Progress of Hydroxycamptothecine Drug Delivery Systems in Anticancer

羟基喜树碱(HCPT)作为有效的广谱抗肿瘤药物广泛用于多种肿瘤的治疗,但存在水溶性差、生理pH不稳定性及体内非特异性分布等缺点,限制了其临床应用。近年纳米技术的发展为药物配制和给药过程提供了新的可能方案,各种纳米递送系统可通过表面修饰及配体偶联靶向传递,实现药物高包封率和高细胞摄取效率。因此,基于药物纳米递送系统的出现为提高HCPT制剂的溶解性、渗透性和稳定性,提高药物疗效、降低不良反应发生率、逆转耐药性提供了新思路、新方法。

Hydroxycamptothecin(HCPT),as an effective broad-spectrum anti-tumor drug,is widely used in the treatment of many kinds of tumors.However,its clinical application is limited due to its poor water solubility,physiological pH instability and non-specific distribution in vivo.In recent years,the development of nanotechnology provides new possibilities for drug preparation and delivery.Various nano delivery systems can achieve high drug entrapment efficiency and high cell uptake efficiency through surface modification and ligand coupling.Therefore,the emergence of drug nano delivery system has provided new ideas and methods for improving the solubility,permeability and stability of HCPT preparations,thus improving drug efficacy,reducing the incidence of adverse reactions and reversing drug resistance.