甲状腺乳头状癌喉前淋巴结转移研究进展

Advances in the study of pre laryngeal lymph node metastasis in papillary thyroid carcinoma

甲状腺乳头状癌在甲状腺恶性肿瘤中属于恶性程度最低、整体预后最好的一种病理类型,但由于其在疾病早期容易发生局部淋巴结转移,增加了术后复发的风险。甲状腺乳头状癌颈部淋巴结转移好发生于中央区,而喉前淋巴结作为中央区的亚区淋巴结,喉前淋巴结的转移是甲状腺乳头状癌或髓样癌的不良预后标志[1]。影响喉前淋巴结转移的因素是多样的,比如中央区淋巴结转移的数量、包膜受侵及肿瘤直径≥1.0cm等因素与喉前淋巴结转移相关[2-3]。目前对于中央区喉前淋巴结转移在甲状腺乳头状癌的疾病进展中的意义研究甚少,故本文着重从喉前淋巴结转移规律及危险因素、喉前淋巴结转移对于甲状腺乳头状癌患者预后的意义等方面进行综述。

Among thyroid malignancies,papillary thyroid carcinoma is a pathological type with the lowest degree of malignancy and the best overall prognosis,but it is prone to local lymph node metastasis in the early stage of the disease,which increases the risk of postoperative recurrence.Cervical lymph node metastasis of thyroid papillary carcinoma is more likely to occur in the central region,while prelaryngeal lymph node is a subregional lymph node in the central region,and prelaryngeal lymph node metastasis is a marker of poor prognosis for papillary or medullary thyroid cancer[1].There are various factors affecting the prelaryngeal lymph node metastasis,such as the number of lymph node metastasis in central region,envelope invasion,tumor diameter ≥1.0cm and other factors that are related to the prelaryngeal lymph node metastasis[2-3].At present,there are few studies on the significance of central prelaryngeal lymph node metastasis in the disease progression of thyroid papillary carcinoma.Therefore,this paper focuses on the review of the regularity and risk factors of prelaryngeal lymph node metastasis,and the significance of prelaryngeal lymph node metastasis in the prognosis of patients with thyroid papillary carcinoma.