摘要
谷胱甘肽过氧化物酶2(Glutathione Peroxidase 2,GPX2)主要聚集于胃肠道组织,以其抗氧化作用保护上皮组织免受过氧化氢、自由基、肿瘤坏死因子等有害物质侵害。GPX2抑制核因子-кB和活性氧介导的肠道炎性通路激活,进而减轻下游炎症物质损伤肠道。本文重点阐述GPX2对动物炎症通路的调控作用及其在动物生产方面的营养调控作用,旨在为维护肠道稳态、预防畜禽肠炎发生提供参考。
Glutathione peroxidase 2(GPX2)is mainly concentrated in gastrointestinal tissues,which protects epithelial tissues from harmful substances such as hydrogen peroxide,free radicals,tumor necrosis factor and so on.GPX2 can inhibit the activation of NF-кB and reactive oxygen species mediated inflammatory pathway in the gut,and then reduce the damage of downstream inflammatory substances to gut.Therefore,this paper focuses on the regulation of GPX2 on animal inflammatory pathway and its application in animal production,in order to provide reference for maintaining intestinal homeostasis and preventing the occurrence of enteritis in livestock and poultry.
作者
杨璐璐
黎力之
关玮琨
廖晓鹏
张海波
郭冬生
YANG Lulu;LI Lizhi;GUAN Weikun;LIAO Xiaopeng;ZHANG Haibo;GUO Dongsheng(College of Life Science and Resources and Environment,Yichun University,Engineering Technology Research Center of Jiangxi Universities and Colleges for Selenium Agriculture,Yichun University,Yichun Key Laboratory of Functional Agriculture and Ecological Environment,Yichun University,Jiangxi Yichun 336000,China;School of Continuing Education,Yichun University,Jiangxi Yichun 336000,China)
出处
《中国畜牧杂志》
CAS
北大核心
2021年第5期48-52,共5页
Chinese Journal of Animal Science
基金
国家地区科学基金项目(32060773)
江西省自然科学基金(20202BABL205010)
江西省现代农业产业技术体系建设专项资金(JXARS-14)
宜春学院科研发展基金项目(kyfzl2020008)
江西省教育厅项目(GJJ190848)。
关键词
谷胱甘肽过氧化物酶2
动物肠道炎症
核因子-кB信号通路
活性氧
Glutathione peroxidase 2
Animal intestinal inflammation
Nuclear factor kappa B signaling pathway
Reactive oxygen species
