甲亢性肝病孕产妇肝功能及甲状腺功能指标改变的临床价值

Clinical value of changes of liver function and thyroid function in patients with hyperthyroidism

目的研究甲状腺功能亢进症(甲亢)性肝病患者肝功能及甲状腺功能指标发生改变的临床意义,并分析其在临床上的作用。方法60例甲亢患者作为对照组(肝功能正常),60例甲亢性肝病患者作为观察组(肝功能异常)。两组患者均给予肝功能指标[总胆汁酸(TBA)、直接胆红素(DBIL)、γ-谷氨酰转肽酶(GGT)、碱性磷酸酶(ALP)、谷草转氨酶(AST)]及甲状腺功能指标[总三碘甲状腺原氨酸(TT3)、总甲状腺素(TT4)、游离三碘甲状腺原氨酸(FT3)、游离甲状腺素(FT4)、促甲状腺激素(TSH)]检验,比较两组检验结果及并发症发生情况。结果观察组并发症发生率86.67%高于对照组的41.67%,差异具有统计学意义(P<0.05)。观察组TBA(25.10±8.56)μmol/L、DBIL(28.45±18.54)μmol/L、GGT(71.89±29.54)U/L、ALP(70.56±30.87)U/L、AST(64.56±24.43)U/L均高于对照组的(12.67±3.21)μmol/L、(22.34±11.21)μmol/L、(61.78±19.10)U/L、(50.78±21.54)U/L、(37.78±17.54)U/L,差异有统计学意义(P<0.05)。观察组TSH(0.41±0.29)mIU/L、FT4(173.88±42.78)pmol/L、FT3(18.92±3.88)pmol/L、TT4(193.32±30.84)nmol/L、TT3(5.52±1.79)nmol/L均高于对照组的(0.31±0.15)mIU/L、(140.37±36.57)pmol/L、(13.62±3.56)pmol/L、(164.38±26.78)nmol/L、(3.26±1.16)nmol/L,差异有统计学意义(P<0.05)。结论甲亢性肝病患者中,其肝功能及甲状腺功能指标改变同肝脏损伤存在紧密的联系,有助于提高检测结果的准确性。此外,一旦指标出现异常,应采取有效干预,继而减少不良反应及并发症。

Objective To study the clinical significance of changes in liver function and thyroid function in patients with hyperthyroidism,and to analyze its clinical role.Methods There were 60 hyperthyroidism patients selected as the control group(with normal liver function),and 60 hyperthyroidism patients selected as the observation group(with abnormal liver function).The liver function indicators[total bile acid(TBA),direct bilirubin(DBIL),γ-glutamyl transpeptidase(GGT),alkaline phosphatase(ALP),aspartate aminotransferase(AST)]and thyroid function indexes[total triiodothyronine(TT3),total thyroxine(TT4),free triiodothyronine(FT3),free thyroxine(FT4),thyroid stimulating hormone(TSH)]of the two groups were tested.The test results and occurrence of complications of the two groups were compared.Results The incidence of complications of the observation group was 86.67%,which was higher than 41.67%of the control group,and the difference was statistically significant(P<0.05).The TBA(25.10±8.56)μmol/L,DBIL(28.45±18.54)μmol/L,GGT(71.89±29.54)U/L,ALP(70.56±30.87)U/L and AST(64.56±24.43)U/L of the observation group were higher than(12.67±3.21)μmol/L,(22.34±11.21)μmol/L,(61.78±19.10)U/L,(50.78±21.54)U/L and(37.78±17.54)U/L of the control group,and the difference was statistically significant(P<0.05).The TSH(0.41±0.29)mIU/L,FT4(173.88±42.78)pmol/L,FT3(18.92±3.88)pmol/L,TT4(193.32±30.84)nmol/L and TT3(5.52±1.79)nmol/L of the observation group were higher than(0.31±0.15)mIU/L,(140.37±36.57)pmol/L,(13.62±3.56)pmol/L,(164.38±26.78)nmol/L and(3.26±1.16)nmol/L of the control group,and the difference was statistically significant(P<0.05).Conclusion In patients with hyperthyroid liver disease,changes in liver function and thyroid function index are closely related to liver damage,which helps to improve the accuracy of detection results.In addition,once the indicators are abnormal,effective intervention should be taken to reduce adverse reactions and complications.