血液透析对慢性肾小球肾炎导致终末期肾病患者血清钙、磷水平的影响

Effect of hemodialysis on serum calcium and phosphorus levels in patients with end-stage renal disease caused by chronic glomerulonephritis

目的探讨慢性肾小球肾炎导致终末期肾病(ESRD)患者经血液透析治疗后血清钙、磷水平的变化及透析期并发症的处理效果。方法50例慢性肾小球肾炎导致终末期肾病患者作为研究对象,均进行血液透析治疗。比较血液透析前、血液透析3个月后的血清钙、磷水平,并发症的发生情况和处理对策。结果血液透析3个月后的血清钙水平为(2.25±0.21)mmol/L,与血液透析前的(2.19±0.20)mmol/L比较,差异无统计学意义(P>0.05);血液透析3个月后的血清磷水平为(1.61±0.39)mmol/L,显著低于血液透析前的(2.23±0.41)mmol/L,差异具有统计学意义(P<0.05)。50例血液透析患者中,有11例出现并发症,并发症发生率为22.0%,包括4例低血压、3例过敏反应、3例失衡综合征、1例发热。经对症处理后,病情好转,无致死性并发症。结论对慢性肾小球肾炎导致终末期肾病患者给予血液透析治疗可改善患者的血清磷水平。

Objective To discuss the changes of serum calcium and phosphorus levels in patients with end-stage renal disease(ESRD)caused by chronic glomerulonephritis after hemodialysis treatment,and the treatment effect of complications during dialysis.Methods 50 patients with end-stage renal disease caused by chronic glomerulonephritis were treated as research subjects,and all underwent hemodialysis treatment.The serum calcium and phosphorus levels before hemodialysis and 3 months after hemodialysis,occurrence of complications and countermeasures were compared.Results 3 months after hemodialysis,the serum calcium of patients was(2.25±0.21)mmol/L,which had no statistically significant difference compared with(2.19±0.20)mmol/L before hemodialysis(P>0.05).3 months after hemodialysis,the serum phosphorus of patients was(1.61±0.39)mmol/L,which was significantly lower than(2.23±0.41)mmol/L,and the difference was statistically significant(P<0.05).Among the 50 hemodialysis patients,11 cases had complications,and the complication rate was 22.0%,including 4 cases of hypotension,3 cases of allergic reactions,3 cases of imbalance syndrome,and 1 case of fever.After symptomatic treatment,the condition improved without fatal complications.Conclusion Hemodialysis can improve serum phosphorus level in patients with end-stage renal disease caused by chronic glomerulonephritis.