内质网相关降解蛋白Derlin-1在子宫内膜癌中的表达及临床意义

Expression and clinical significance of endoplasmic reticulum-related degradation protein-1 in endometrial carcinoma

目的探讨子宫内膜癌组织中内质网相关降解蛋白Derlin-1的表达及临床意义。方法选取2010年1月至2019年1月南京医科大学附属无锡人民医院病理科的160例患者的石蜡块标本作为研究对象。50例正常子宫内膜蜡块纳入正常组,50例不典型增生蜡块纳入增生组,60例子宫内膜癌蜡块纳入子宫内膜癌组。利用免疫组织化学法检测Derlin-1蛋白表达,并分析其与临床病理特征的关系。结果正常组、增生组、子宫内膜癌组Derlin-1阳性表达率呈上升趋势(36.0%、56.0%、80.0%),差异具有统计学意义(χ^(2)=22.014,P=0.000)。子宫内膜癌组不同FIGO分期、组织分级、肌层肿瘤深度Derlin-1阳性表达率比较,差异具有统计学意义(P<0.05),不同年龄、是否绝经和是否淋巴结转移的Derlin-1阳性表达率比较,差异无统计学意义(P>0.05)。Derlin-1阳性表达与FIGO分期、组织分级、肌层肿瘤深度密切相关,是子宫内膜癌发病的独立危险因素(P<0.05)。结论Derlin-1在子宫内膜癌组织中高表达可能与子宫内膜癌的发生发展有关。

Objective To investigate the expression and clinical significance of endoplasmic reticulum-related degradation protein Derlin-1 in endometrial carcinoma.Methods Paraffin blocks were collected from 160 patients in the Department of Pathology,Wuxi People′s Hospital Affiliated to Nanjing Medical University from January 2010 to January 2019.50 cases of normal endometrial blocks were included in the normal group,50 cases of atypical hyperplasia were included in the hyperplasia group,and 60 cases of endometrial cancer blocks were included in the endometrial cancer group.The expression of Derlin-1 protein was detected by immunohistochemistry,and the relationship between Derlin-1 protein expression and clinicopathological characteristics was analyzed.Results The positive expression rate of Derlin-1 in normal group,hyperplasia group and endometrial carcinoma group was increased(36.0%,56.0%,80.0%),and the difference was statistically significant(χ^(2)=22.014,P=0.000).There was statistically significant difference in the positive expression rate of Derlin-1 among endometrial cancer group with different FIGO stages,tissue grade and muscle layer tumor depth(P<0.05),while there was no statistically significant difference in the positive expression rate of Derlin-1 among endometrial cancer group with different age,menopause or lymph node metastasis(P>0.05).The positive expression of Derlin-1 was closely correlated with FIGO stage,tissue grade and depth of muscular tumor,and was an independent risk factor for endometrial cancer(P<0.05).Conclusions The high expression of Derlin-1 protein in endometrial carcinoma may be related to the carcinogenesis and development of endometrial carcinoma.