运用数据挖掘法浅析陈其华教授治疗前列腺癌用药规律

Analysis on the rule of Professor Chen Qihua′s medication for prostate cancer with data mining

目的运用数据挖掘法分析陈其华教授治疗前列腺癌的用药规律。方法选取2017年10月至2019年10月陈其华教授在湖南中医药大学第一附属医院治疗的前列腺癌患者作为研究对象。共纳入337首有效处方。采用关联规则分析、复杂系统熵聚类分析等数据挖掘方法进行分析。结果共纳入处方337首,涉及药物98味,频数>100次的药物共16味。药物四气以温、寒、平为主;五味以甘、辛、苦为主;归经以肝、肾、脾为主。频数>40次的药对共24个,前5位分别为黄芪-茯苓(207次)、黄芪-甘草(173次)、茯苓-甘草(165次)、黄芪-鹿角胶(147次)、茯苓-鹿角胶(141次);聚类分析共获得6个核心药对及5个新药物组合。结论陈其华教授治疗前列腺癌以辨证论治为基础,遵循"扶正祛邪、温阳化气"的治疗原则,同时兼顾阴阳气血盛衰,药物以补益药、活血祛瘀药以及化痰散结药为主,体现"扶正祛邪""以通为用"及"病证结合"的用药思路。

Objective To analyze on the rule of Professor Chen Qihua′s medication for prostate cancer with data mining.Methods Patients with prostate cancer treated by Professor Chen Qihua in the First Affiliated Hospital of Hunan University of Chinese Medicine from October 2017 to October 2019 were selected as the research subjects.A total of 337 effective prescriptions were included.Data mining methods such as association rule analysis and complex system entropy clustering analysis were used to analyze the data.Results A total of 337 prescriptions were included,involving 98 drugs,and 16 drugs with frequency>100 times.As to the four Qi of medicine,warm,cold and flat were mainly used.To the five Flavors,sweet,spicy and bitter are mainly used;The main meridians are liver,kidney and spleen.There were 24 drug pairings with the frequency of>40 times,and the top 5 were Astragalus-Poria(207 times),Astragalus-Licorice(173 times),Poria Coing-Licorice(165 times),Astragalus-Staghorn gum(147 times),and Poria Coing-Staghorn gum(141 times).Six core drug pairs and five new drug combinations were obtained by cluster analysis.Conclusions Professor Chen Qihua′s treatment on prostate cancer is based on syndrome differentiation and treatment,following the principle of"reinforcing the body and eliminating pathogenic factors,warming yang and transforming qi",while taking into account the rise and fall of yin and yang qi and blood.The drugs are mainly tonifying drugs,to promote blood circulation and remove blood stasis,and to dissolve phlegm and disperse constipation,which reflecting the medication idea of"strengthening the body and eliminating evils","using the general purpose"and"combining disease and syndrome".