穴位贴敷联合补肾活血法治疗复发性流产的临床效果研究

Clinical effect of acupoint application combined with kidney-tonifying and blood-activating on recurrent spontaneous abortion

目的分析穴位贴敷联合补肾活血法对复发性流产(RSA)的临床疗效。方法选取2017年1月至2019年1月石家庄市中医院收治的90例RSA患者为研究对象。采用随机数字表法分为A组(n=30)、B组(n=30)和C组(n=30)。其中A组给予西药治疗,B组给予西药+补肾活血法治疗,C组给予西药+穴位贴敷+补肾活血法治疗。对比三组治疗前后中医症状评分,治疗后抗心磷脂抗体(ACA)转阴率、临床疗效,治疗前后血清β-人绒毛膜促性腺激素(β-HCG)、孕酮(P)水平和血小板最大聚集率。结果与治疗前比较,三组治疗后主症评分、次症评分和总症状评分均下降,且C组<B<A组(P<0.05);C组ACA转阴率及总有效率显著高于A组和B组(P<0.01);与治疗前比较,治疗后三组β-HCG、P水平均升高,且C组>B组>A组(P<0.05);血小板最大聚集率均降低,且C组<B组<A组(P<0.05)。结论针对RSA患者在常规西药治疗的基础上,加以穴位贴敷联合补肾活血法的中医综合治疗,可以更大程度缓解患者临床症状,提高ACA转阴率以及β-HCG、P水平,降低血小板最大聚集率,提升临床疗效。

Objective To investigate the clinical effect of acupoint application combined with kidney-tonifying and blood-activating on recurrent spontaneous abortion(RSA).Methods 90 patients with RSA admitted to Shijiazhuang Hospital of Traditional Chinese Medicine from January 2017 to January 2019 were selected as the research subjects,and divided into group A(n=30),group B(n=30)and group C(n=30)by random number table method.Among them,group A was treated with western medicine,group B was treated with western medicine+kidney-tonifying and blood-activating method,and group C was treated with western medicine+acupoint application+kidney-tonifying and blood-activating method.TCM symptom scores,anti-cardiolipin antibody(ACA)negative conversion rate,clinical efficacy,serumβ-human chorionic gonadotropin(β-HCG),progesterone(P)levels and maximum platelet aggregation rate were compared between the three groups before and after treatment.Results Compared with before treatment,primary symptom score,secondary symptom score and total symptom score in the three groups decreased after treatment,and group C<group B<group A(P<0.05);The negative conversion rate and total effective rate of ACA in group C were significantly higher than those in groups A and B(P<0.01);the levels ofβ-HCG and P in three groups increased after treatment,and the levels of group C>group B>group A(P<0.05);The maximum platelet aggregation rate decreased,and group C<group B<group A(P<0.05).Conclusions For patients with RSA,on the basis of conventional western medicine treatment,combined with acupoint application and kidney-tonifying and blood-activating method of Chinese medicine comprehensive treatment,can alleviate the clinical symptoms of patients to a greater extent,improve the negative rate of ACA andβ-HCG,P levels,reduce the maximum platelet aggregation rate,improve clinical efficacy.