酮康唑联合苦参凝胶阴道用药对复发性霉菌性阴道炎患者症状及炎症因子水平的影响

Effect of ketoconazole combined with sophora gel on symptom and inflammatory factor level in patients with recurrent mycotic vaginitis

目的探讨酮康唑联合苦参凝胶阴道用药对复发性霉菌性阴道炎患者症状及炎症因子水平的影响。方法选取2017年10月至2018年10月无锡市第五人民医院收治的80例复发性霉菌性阴道炎患者作为研究对象。按照随机数字表法分为观察组(n=40)和对照组(n=40)。对照组接受酮康唑治疗,观察组在此基础上联合苦参凝胶阴道用药治疗。对比两组临床疗效、复发率、炎症因子水平、症状改善时间、不良反应等指标。结果观察组总有效率高于对照组,复发率低于对照组(P<0.05);治疗后两组C反应蛋白(CRP)、白介素-6(IL-6)水平均低于治疗前,且观察组CRP、IL-6水平均低于对照组(P<0.05);观察组外阴疼痛消失时间、黏膜充血消失时间、外阴瘙痒消失时间均短于对照组(P<0.05);两组不良反应发生率差异无统计学意义(P>0.05)。结论酮康唑联合苦参凝胶阴道用药治疗复发性霉菌性阴道炎可改善患者的临床症状,降低炎症因子水平,临床疗效高,且复发率较低。

Objective To explore the effect of ketoconazole combined with sophora gel on symptom improvement and inflammatory factor level in patients with recurrent mycotic vaginitis.Methods 80 patients with recurrent mycotic vaginitis admitted to Wuxi Fifth People′s Hospital from October 2017 to October 2018 were selected as the research subjects.According to random number table method,they were divided into observation group(n=40)and control group(n=40).The control group was treated with ketoconazole,and the observation group was combined with Sophora flavescens gel.Clinical efficacy,recurrence rate,inflammatory cytokine level,symptom improvement time,adverse reactions and other indicators were compared between the two groups.Results The total effective rate of observation group was higher than control group,and the recurrence rate of observation group was lower than control group(P<0.05).After treatment,CRP and IL-6 in both groups were lower than before,and the levels of CRP and IL-6 in observation group were lower than those in control group(P<0.05).The disappearance time of vulva pain,mucosal congestion and vulva pruritus in observation group were shorter than those in control group(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions Ketoconazole combined with matrine gel for vaginal treatment of recurrent mycotic vaginitis can improve the clinical symptoms of patients,reduce the level of inflammatory factors,with high clinical efficacy and low recurrence rate.