双相情感障碍患者血清胰岛素样生长因子-1水平的研究

The Expression of Serum Insulin-like Growth Factor 1 in Bipolar Disorder

目的:评估双相情感障碍患者血清胰岛素样生长因子-1(IGF-1)水平,同时检测血清生长激素(GH)、胰岛素(FINS)和肿瘤坏死因子(TNF-α)水平。方法:研究组纳入符合ICD-10中双相情感障碍诊断标准的稳定期患者(n=40),纳入无精神疾病家族史的健康对照者(n=40)为对照组,使用哈密尔顿抑郁量表-17项(HAMD-17)和杨氏躁狂量表(YMRS)评估研究组患者抑郁、躁狂症状;使用临床总体印象量表(CGI-S)评估患者疾病严重程度,检测两组血清IGF-1、FINS、GH和TNF-α水平。对相关数据选用独立t检验、曼-惠特尼检验、斯皮尔曼相关系数等统计方法。结果:研究组血清IGF-1水平高于对照组,两组比较差异有统计学意义(P=0.001);研究组血清IGF-1水平与CGI-S、HAMD、YMRS分值无显著相关性(P>0.05);两组血清FINS、GH、TNF-α水平比较差异无统计学意义(P>0.05)。结论:研究表明双相情感障碍患者外周血清IGF-1水平显著升高,可能与双相情感障碍病理生理机制有关。

Objective:To evaluate serum levels of insulin-like growth factor 1(IGF-1),growth hormone(GH),fast insulin(FINS)and tumor necrosis factor(TNF-α)in bipolar disorder patients.Methods:Included 40 patients with bipolar disorder in stable period and 40 healthy controls.Assessed depressive and manic symptoms,respectively,administered the Hamilton Depression Rating Scale-17(HAMD-17)and the Young Mania Rating Scale(YMRS).Clinical Global Improvement(CGI)was administered to evaluate the severity of the illness.Serum concentrations of IGF-1,GH,FINS and TNF-αwere analyzed and compared between the two groups.Results:The serum IGF-1 level of the study group was higher than that of the control group,the difference between the two groups was statistically significant(P=0.001).Correlations between serum levels of IGF-1 and CGI,HAMD,YMRS were not statistically significant.There was no significant difference between groups in the concentration of FINS,GH,and TNF-α(P>0.05).Conclusion:The serum levels of IGF-1 in bipolar disorder patients are significantly increased,which is closely related to the pathophysiology of bipolar disorder.