新生儿败血症500例病原菌分布及耐药状况分析

Distribution and Drug Resistance of Pathogenic Bacteria in 500 Cases of Neonatal Septicemia

目的:分析新生儿败血症病原菌的分布及耐药状况。方法:对2016年1月至2018年6月期间苏州市立医院接诊的500例败血症的新生儿血培养资料进行回顾性分析,探讨血培养病原菌的构成及耐药性。结果:其中革兰阳性菌42株,所占比例60.00%,革兰阴性菌28株,所占比例40.00%;革兰阳性菌中表皮葡萄球菌检出率最高;革兰阴性菌中大肠埃希菌检出率最高。大肠埃希菌与肺炎克雷伯菌对氨苄西林的耐药性最高,均为100.00%,表皮葡萄球菌对氨苄西林的耐药性为85.71%,大肠埃希菌与肺炎克雷伯菌对复方磺胺甲噁唑的耐药性分别为83.33%与75.00%,对庆大霉素的耐药性也超过了50.00%。结论:病原菌以表皮葡萄球菌为主,主要病原菌对氨苄西林与复方磺胺甲噁唑以及庆大霉素的耐药性较高。

Objective:To analyze the distribution and drug resistance of pathogenic bacteria in neonatal septicemia.Methods:The blood culture data of 500 cases of septicemia received from Suzhou Municipal Hospital from January 2016 to June 2018 were analyzed retrospectively to explore the composition and drug resistance of blood culture pathogens.Results:Among them,42 strains were gram-positive bacteria(60.00%)and 28 strains were gram-negative bacteria(40.00%).The detection rate of Staphylococcus epidermidis was the highest in gram-positive bacteria,the detection rate of Escherichia coli was the highest in gram-negative bacteria.The detection rate of Staphylococcus epidermidis and Escherichia coli was the highest in early-onset neonates,followed by Klebsiella pneumoniae.The resistance of Escherichia coli and Klebsiella pneumoniae to ampicillin was the highest(100.00%).The resistance of Staphylococcus epidermidis to ampicillin was 85.71%.The resistance of Escherichia coli and Klebsiella pneumoniae to compound sulfamethoxazole was 83.33%and 75.00%respectively.The resistance to gentamicin was more than 50.00%.Conclusion:Staphylococcus epidermidis is the main pathogen of neonatal septicemia.The main pathogens are resistant to ampicillin,compound sulfamethoxazole and gentamicin.