阿莫西林与左氧氟沙星三联疗法对活动性慢性胃炎患者幽门螺杆菌感染的临床效果比较

Comparison of Clinical Effect of Amoxicillin and Levofloxacin Triple Therapy on Helicobacter Pylori Infection in Patients with Active Chronic Gastritis

目的:分析阿莫西林与左氧氟沙星三联疗法对活动性慢性胃炎患者幽门螺杆菌(Hp)感染的临床效果。方法:选取2018年7月至2020年2月期间北京市大兴区中西医结合医院收治的Hp感染活动性慢性胃炎患者86例,按随机数字表法分为观察组(n=43)和对照组(n=43),对照组予以阿莫西林三联疗法治疗,观察组予以左氧氟沙星三联疗法治疗。对比两组疗效、不良反应发生率及治疗前后血清炎性因子[一氧化氮(NO)、转化生长因子-β1(TGF-β1)]水平变化。结果:观察组总有效率97.67%高于对照组76.74%(P<0.05);治疗后,观察组血清NO水平较对照组高,TGF-β1水平较对照组低(P<0.05);观察组不良反应发生率2.33%与对照组6.98%比较,差异无统计学意义(P>0.05)。结论:左氧氟沙星三联疗法治疗Hp感染活动性慢性胃炎患者可提高疗效,改善炎症状态,促进幽门螺杆菌根除,且不良反应发生率低,值得推广应用。

Objective:To analyze the clinical effect of combination of amoxicillin and levofloxacin on Helicobacter pylori(Hp)infection in patients with active chronic gastritis.Methods:From July 2018 to February 2020,86 patients with Hp infection active chronic gastritis were selected from Daxing Integrated Traditional Chinese and Western Medicine Hospital of Beijing.They were divided into observation group(n=43)and control group(n=43),the control group was treated with amoxicillin triple therapy,the observation group was treated with levofloxacin triple therapy.The efficacy,incidence of adverse reactions and changes in serum inflammatory factors[nitric oxide(NO),transforming growth factorβ1(TGF-β1)]before and after treatment were compared between the two groups.Results:The total effective rate of observation group was 97.67%higher than that of control group 76.74%(P<0.05);after treatment,serum NO level in observation group was higher than in control group,the TGF-β1 level was lower than that of the control group(P<0.05);compared with the control group 6.98%,there was no significant difference in the incidence of adverse reactions(P>0.05).Conclusion:Levofloxacin triple therapy can improve the efficacy of Hp infection in patients with active chronic gastritis,improving inflammation,promoting Helicobacter pylori eradication,and the incidence of adverse reactions is low,it is worth popularizing and applying.