胰腺癌抗纤维化治疗研究进展

Research advances in anti-fibrosis therapy for pancreatic cancer

胰腺癌的恶性程度高、侵袭性强、生存率低,其肿瘤微环境中高度的间质纤维化在胰腺癌发生和发展过程中具有重要作用,并严重影响胰腺肿瘤的治疗效果。近年来,逆转胰腺癌纤维化肿瘤微环境已经成为胰腺癌治疗的新思路。基于此,本文分别从靶向间质细胞(胰腺星状细胞和相关成纤维细胞)、靶向间质成分(胶原和透明质酸)和靶向纤维化机制(上皮-间充质转化、hedgehog信号途径和伤口愈合)三个方面综述了胰腺癌在抑制纤维化治疗方面的最新研究进展,并对当前纤维化研究中细胞与动物纤维化模型的构建进行了介绍,以期为胰腺癌的肿瘤微环境治疗提供参考。

Pancreatic cancer is a highly aggressive malignancy with a low survival rate.The high degree of interstitial fibrosis in the tumor microenvironment of pancreatic cancer plays an important role in the occurrence and development of pancreatic cancer,and seriously affects the therapeutic effects of pancreatic tumors.In recent years,reversing the tumor microenvironment of pancreatic cancer fibrosis has become a new strategy in the treatment of pancreatic cancer.On these basis,this article summarizes the latest research progress in inhibiting fibrosis treatment of pancreatic cancer from three perspectives,including the targeted mesenchymal cells treatment(pancreatic stellate cells and related fibroblasts),the targeted stromal elements treatment(collagen and hyaluronic acid)and the targeted fibrosis mechanism treatment(epithelial-mesenchymal transformation,hedgehog signaling pathways and wound healing).The construction of cell and animal fibrosis models in current anti-fibrosis research is also introduced,so as to provide references for the tumor microenvironment treatment of pancreatic cancer.