脑梗死合并脑血管动脉狭窄患者血清炎性因子、同型半胱氨酸与CIMT的关系

Relationship between Serum Inflammatory Factors,Homocysteine and CIMT in Patients with Cerebral Infarction Complicated with Cerebral Artery Stenosis

目的:分析探讨脑梗死合并脑血管动脉狭窄患者血清炎性因子、同型半胱氨酸(Hcy)与颈动脉内膜中层厚度(CIMT)的关系。方法:选取本院2018年6月-2019年12月收治的急性脑梗死合并脑血管动脉狭窄患者180例作为研究对象。根据患者脑动脉狭窄程度分为动脉狭窄Ⅰ级组(狭窄50%以下,50例)、动脉狭窄Ⅱ级组(狭窄50%~69%,70例)、动脉狭窄Ⅲ级组(狭窄69%以上,60例)。根据CIMT值将患者分为内膜正常组、内膜增厚组、斑块形成组三组。多普勒超声检测患者CIMT,检测患者血清炎性因子和Hcy水平,分析血清炎性因子、Hcy与CIMT的关系。结果:血清CRP、ESR、PCT、CIMT值、Hcy水平在狭窄Ⅰ级组、狭窄Ⅱ级组、狭窄Ⅲ级组中依次增高,血清CRP、ESR、PCT、Hcy水平内膜正常组、内膜增厚组、斑块形成组依次增高,差异有统计学意义(P<0.05)。脑梗死合并脑血管动脉狭窄患者CIMT与CRP、ESR、PCT和Hcy呈正相关(r=0.567、0.508、0.525、0.581,P<0.05)。结论:脑梗死合并脑血管动脉狭窄患者血清炎性因子、Hcy与CIMT有关,能较好地反映患者CIMT的变化,值得临床上大力推广使用。

Objective:To analyze the relationship between serum inflammatory factors,homocysteine ??(Hcy) and carotid intima-media thickness (CIMT) in patients with cerebral infarction complicated with cerebral artery stenosis.Method:A total of 180 patients with acute cerebral infarction and cerebrovascular artery stenosis admitted to our hospital from June 2018 to December 2019 were selected as the research objects.All patients met the diagnostic criteria issued by China Neuroscience.According to the degree of cerebral artery stenosis,the patients were divided into the arterial stenosis Ⅰ group (stenosis below 50%,50 cases),the arterial stenosis grade Ⅱ group (stenosis 50%-69%,70 cases) and the arterial stenosis grade Ⅲ group (stenosis above 69%,60 cases).According to the CIMT value,the patients were divided into three groups:the intima normal group,the intima thickening group,the plaque formation group.CIMT was detected by Doppler ultrasonography.Detected the serum inflammatory factors and Hcy levels,and analyzed the relationship between serum inflammatory factors,Hcy and CIMT.Result:The levels of serum CRP,ESR,PCT,CIMT and Hcy in the arterial stenosis grade Ⅰ,Ⅱ and Ⅲ groups were increased in turn,while the levels of CRP,ESR,PCT and Hcy in the intima normal group,the intima thickening group,the plaque formation group were increased in turn,the differences were statistically significant (P<0.05).There were positive correlations between carotid CIMT and CRP,ESR,PCT,Hcy (r=0.567,0.508,0.525,0.581,P<0.05).Conclusion:Serum inflammatory factors and Hcy in patients with cerebral infarction complicated with cerebral artery stenosis are related to carotid CIMT,which can better reflect the changes of CIMT in patients with cerebral infarction,which is worthy of clinical application.