马来酸氟伏沙明联合阿普唑仑治疗抑郁发作伴焦虑症状的临床效果

Clinical Efficacy of Fluvoxamine Maleate Combined with Alprazolam in the Treatment of Depression Accompanied by Anxiety Symptoms

目的:探讨马来酸氟伏沙明联合阿普唑仑治疗抑郁发作伴焦虑症状的临床效果。方法:选取2018年8月-2020年8月本院诊治的110例抑郁发作伴焦虑症状患者,按照随机数字表法分为对照组与观察组,各55例。对照组仅采用马来酸氟伏沙明治疗,观察组在此基础上联合阿普唑仑治疗。比较两组临床疗效及不良反应发生率。结果:(1)观察组临床总有效率为94.55%,显著高于对照组的70.91%(P<0.05);(2)两组患者治疗后HAMD评分及HAMA评分较治疗前均显著降低(P<0.05),且观察组患者治疗后评分低于对照组(P<0.05);(3)观察组不良反应总发生率为14.55%,显著低于对照组的30.91%(P<0.05)。结论:马来酸氟伏沙明联合阿普唑仑,较单独使用马来酸氟伏沙明治疗抑郁发作伴发焦虑症状起效快,较安全,效果显著。

Objective:To investigate the clinical efficacy of Fluvoxamine Maleate combined with Alprazolam in the treatment of depression accompanied by anxiety symptoms.Method:From August 2018 to August 2020,110 patients with depression accompanied by anxiety symptoms admitted to our hospital were divided into the control group and the observation group according to the random number table method,55 cases in each group.The control group was treated with Fluvoxamine Maleate only.On this basis,the observation group was treated with Alprazolam.The clinical efficacy and the incidence of adverse reactions were compared between the two groups.Result:(1) The total clinical effective rate was 94.55% in the observation group,which was significantly higher than 70.91% in the control group (P<0.05).(2) The HAMD score and HAMA score in both groups were significantly lower after treatment than before (P<0.05),and the scores in the observation group were significantly lower than those in the control group (P<0.05).(3) The total incidence of adverse reactions in the observation group was 14.55%,significantly lower than 30.91% in the control group (P<0.05).Conclusion:The efficacy of Fluvoxamine Maleate combined with Alprazolam was faster,safer and more effective than that of Fluvoxamine Maleate alone in the treatment of depression accompanied by anxiety symptoms.