儿童肾病综合征采用双嘧达莫配合泼尼松治疗对肾功能及凝血指标的影响

Effect of Dipyridamole Combined with Prednisone on Renal Function and Coagulation Index in Children with Nephrotic Syndrome

目的:探究采用双嘧达莫配合泼尼松治疗儿童肾病综合征的效果,以及治疗对肾功能、凝血指标产生的影响。方法:选择本院2017年12月-2019年12月收治的98例儿童肾病综合征患儿作为研究对象,基于随机数表法将患儿划分成对照组(n=49)与试验组(n=49)。对照组采用常规方法,试验组采用基础治疗联合双嘧达莫、泼尼松。对比两组治疗前后肾功能指标、凝血指标变化及多尿与水肿消退时间。结果:治疗后两组患儿肾功能血清肌酐浓度(Scr)、尿素氮(BUN)、铜蓝蛋白(Cer)、24 h尿蛋白四项指标均有所改善,但试验组改善情况更佳,与对照组比较差异有统计学意义(P<0.05)。治疗后,对照组凝血酶原时间(PT)超出正常范围值,试验组维持在正常水平内,差异有统计学意义(P<0.05);两组血小板(PLT)、活化部分凝血活酶时间(APTT)两项指标均维持在正常水平,两组PLT比较,差异无统计学意义(P>0.05);试验组APTT高于对照组(P<0.05)。试验组多尿与水肿两项症状消退时间明显早于对照组(P<0.05)。结论:双嘧达莫配合泼尼松治疗小儿肾病综合征效果显著,对肾功能及凝血指标有着积极影响,加速患儿恢复,改善临床症状,建议广泛应用于临床。

Objective:To explore the effect of Dipyridamole combined with Prednisone in the treatment of children with nephrotic syndrome and the influence of treatment on renal function and coagulation indexes.Method:A total of 98 children with nephrotic syndrome in our hospital from December 2017 to December 2019 were selected as the research objects,and the children were divided into the control group(n=49)and the experimental group(n=49)based on random number table method.The control group was treated with conventional methods,and the experimental group was treated with basic therapy combined with Dipyridamole and Prednisone.The changes in renal function indexes,coagulation indexes,and the time to resolution of polyuria and edema before and after treatment were compared between the two groups.Result:After treatment,serum creatinine concentration(Scr),urea nitrogen(BUN),ceruloplasmin(Cer)and 24-hour urinary protein of the two groups were improved,but the improvement of the experimental group were better than those of the control group(P<0.05).After treatment,the prothrombin time(PT)of the control group was beyond the normal range,while the experimental group was maintained at the normal level,the difference was significant difference(P<0.05);the two indexes of platelet(PLT)and activated partial thromboplastin time(APTT)in the two groups were maintained at the normal level,the PLT in two groups had no significant difference(P>0.05);the APTT in the experimental group was higher than that in the control group(P<0.05).The disappearance time of polyuria and edema in the experimental group were significantly earlier than those in the control group(P<0.05).Conclusion:Dipyridamole combined with Prednisone in the treatment of children with nephrotic syndrome has a significant effect,has a positive impact on renal function and coagulation indicators,can accelerate the recovery of children,and improve clinical symptoms.It is recommended to be widely used in clinical.