非离子表面活性剂囊泡(niosome)的研究进展——制备、表征及化妆品应用(续完)

Research progress in nonionic surfactant vesicles(niosomes):fabrication,characterization and cosmetic applications

5表征niosome的表征参数包括尺寸、分布、zeta电势、形貌、包封率(EE)和体外释放行为等。研究这些是为了在配方开发中确定niosome的品质,进而评判其在未来的临床研究中的应用性。这些参数直接影响稳定性和体内性能[2,8]。表2对其进行了总结,并在下面进行了更详细的讨论。

During the last decade,a lot of interest has been drawn on the fabrication of surfactant-based vesicles.As a class of nanocarriers for drug delivery,they have potential to improve drug delivery.Niosomes are self-assembled vesicular nano-carriers formed by hydration of non-ionic surfactant,cholesterol or other amphiphilic molecules that serve as a versatile drug delivery system with a variety of applications ranging from dermal delivery to brain-targeted delivery.Herein,a large number of research articles have been reviewed,including the fabrication methods of niosomes and their applications in cosmetic field.Niosomes have the same advantages as liposomes,such as the ability to incorporate both hydrophilic and lipophilic compounds.Besides,niosomes can be fabricated with simple methods,require less production cost and are stable over an extended period,thus overcoming the major drawbacks of liposomes.A summary of niosomal research to date has been provided,including the formulation components,types of niosomes,effects of components on the formation of niosomes,fabrication and purification methods,physical characterization techniques of niosomes,and recent applications in cosmetic field.Finally,limitations and the future outlook for this system have also been discussed.