荔枝核治疗肝脏疾病研究进展

Research Progress of Litchi Seed in the Treatment of Hepatic Diseases

综述荔枝核在抗乙肝病毒、抗肝纤维化及保护肝细胞、降血脂减轻脂肪肝、抑制肝癌及增强免疫等4个方面治疗肝脏疾病的相关研究进展,指出目前实验研究较多停留在荔枝核的粗提取物方面,缺乏具体、准确的生物药剂学与药物动力学等方面的研究,且荔枝核在治疗肝脏疾病方面完整、准确的分子机制及其信号传导通路尚无法明确,今后需进一步深入研究。

Research progress of litichi seed in the treatment of hepatic diseases was reviewed from four aspects:anti-HBV,anti-fibrosis and protecting liver cells,reducing blood lipid and relieving fatty liver,inhibiting liver cancer and enhancing the immunity,etc,it is pointed out that most of the experimental studies only stay on the crude extract of litchi seed,and lack of specific and accurate research on biopharmaceutics and pharmacokinetics,the complete and accurate molecular mechanism and signal transduction pathway of litchi seed in the treatment of hepatic disease are still unclear,and the future experimental research needs to be further studied.