C—H键活化苯一步合成苯酚的研究

One-step synthesis of phenol from benzene by C—H bond activation

活化C—H键直接将羟基引入芳香环是苯酚合成化学中的难题。采用自主研发的常压低能电晕放电技术,利用搭建的电晕针阵列制备苯酚的有机合成装置,在优化实验条件下由水二聚体自由基阳离子[(H_(2)O)_(2)^(+)·]与苯反应制备苯酚。结果表明,在常温常压下,仅消耗极低的电能即可高效制备苯酚,其苯酚的法拉第效率高达60%。电晕放电阵列技术以及(H_(2)O)_(2)^(+)·的高反应活性有利于苯一步羟基化合成苯酚。

It is one of the greatest challenges in synthetic chemistry of phenol to graft directly hydroxyl group into aromatic ring to generate corresponding hydroxyl compounds through activating C—H bond.Phenol is prepared through the reaction between dimeric water radical cations and benzene by using the self-built organic synthesis device containing corona discharge needles array based on the self-developed low energy corona discharge technology.The results indicate that phenol can be efficiently produced under normal temperature and pressure conditions,with extreme low power consumption as well as high faraday efficiency even as high as 60%.Through combination between the advantages of corona discharge needles array technology and the high reactivity of dimeric water radical cations,this method is a proper candidate process for one-step hydroxylation of benzene to phenol.