SBA-15和SBA-16介孔二氧化硅的载药及释药行为研究

Investigation on drug-loading and drug-releasing behaviors of SBA-15 and SBA-16 mesoporous silica carriers

采用水热合成法制备了SBA-15和SBA-16介孔二氧化硅载体材料,利用浸渍法将模型药布洛芬负载于2种载体上,通过溶出实验测定了载药后载体的释药行为,并利用SEM、TEM、IR、XRD、N2吸附-脱附对载药后载体材料的结构进行了表征。结果表明,SBA-15和SBA-16的载药量分别为30%和29%,药物成功装载于介孔孔道中没有影响介孔二氧化硅的骨架结构,但孔径、孔容及比表面积都有所降低。药物负载于SBA-15载体上呈速释特性,负载于SBA-16载体上呈缓释特性。

SBA-15 and SBA-16,two kinds of mesoporous silica carriers,are synthesized through hydrothermal synthesis method.Ibuprofen,as a model drug,is loaded on these two carriers respectively by impregnation method.The release behaviors of the drug are determined by dissolution test.SEM,TEM,IR,XRD and N2 adsorption-desorption are utilized in investigating the structure of drug-loading carriers.It is shown that the drug loading amount of SBA-15 and SBA-16 are 30%and 29%,respectiely.Drug has successfully been loaded on the mesoporous channel of the carriers without impacting on their skeleton structure,but the pore diameter,pore volume and specific surface area of the carriers decreases.The drug loaded on SBA-15 carrier shows a quick release characteristics and the drug loaded on SBA-16 carrier shows a sustained release characteristics.