肠道菌群在系统性红斑狼疮中的研究进展

Progress of gut microbiota in systemic lupus erythematosus

系统性红斑狼疮(SLE)是一种可累及多系统及多脏器的自身免疫性疾病,可导致机体较为明显的免疫功能紊乱,但发病机制尚未完全明确。机体肠道系统中寄居大量细菌,种类繁多,数量庞大。正常情况下,菌群数量及种类保持平衡,与机体互利共生,共同维持机体正常生长与发育,但异常情况下,菌群数量及种类发生改变,引起免疫系统紊乱,进而导致疾病发生与发展。SLE与肠道菌群紊乱关系密切,肠道菌群参与SLE的免疫调节环节。本文就肠道菌群在SLE中的研究进展进行综述。

Systemic lupus erythematosus(SLE)is an autoimmune disease involving multiple systems and organs,which can cause relatively obvious immune dysfunction in body,and pathogenesis of SLE is still not completely clear up to now.There are a lot of various bacteria in intestinal system.Under normal condition,bacteria maintain a balance in species and quantity,which are symbiotic mutually with host and jointly maintain normal growth and development.However,under abnormal condition,species and quantity of bacteria in intestinal system will be changed,which can cause disorder of immune system and disease,and further lead to occurence and development of disease.SLE is closely related to disorder of gut microbiota.In this paper,progress of gut microbiota in systemic lupus erythematosus was reviewed.