TWEAK、NT-proBNP表达情况和ADO指数与COPD患者生存状况的关系分析

Analysis of relationship between expression of TWEAK,NT-proBNP and ADO index and survival of patients with COPD

目的:研究肿瘤坏死因子样弱凋亡诱导因子(TWEAK)、N末端脑钠肽前体(NT-proBNP)表达情况和ADO指数与慢性阻塞性肺疾病(COPD)患者生存状况的关系。方法:选取我院于2016年5月至2017年12月期间收治的106例COPD患者为研究对象,回顾性分析入组患者病历资料,并统计2年内生存情况。根据患者生存情况分为生存组和死亡组,比较两组患者TWEAK、NT-proBNP表达情况及ADO指数。采用Logistic回归分析判断影响患者生存的危险因素,log-rank检验比较组间生存率。结果:随访2年,死亡25例(23.58%)。死亡组患者的病程、血浆TWEAK和NT-proBNP水平以及ADO指数评分均明显高于存活组,差异有统计学意义(P<0.05)。血浆TWEAK、NT-proBNP高表达患者的死亡率明显高于低表达组,高ADO指数评分患者的死亡率明显高于低评分组(P<0.05)。Pearson相关性分析显示血浆NT-proBNP、TWEAK水平与ADO指数评分呈正相关(r=0.613,0.684;P<0.001)。Logistic回归分析显示病程、血浆TWEAK和NT-proBNP水平及ADO指数评分是影响COPD患者生存情况的独立危险因素(P<0.05)。结论:TWEAK、NT-proBNP表达情况和ADO指数均是COPD患者生存状况的独立危险因素,各指标水平越高则死亡风险越高。

Objective:To study the relationship between expression of TWEAK,NT-proBNP and ADO index and survival of patients with COPD.Methods:106 patients with COPD admitted to our hospital from May 2016 to December 2017 were selected as research objects,medical records of the enrolled patients were retrospectively analyzed,and the survival situation within 2 years was counted.Patients were divided into survival group and death group according to their survival situation,and expressions of TWEAK,NT-proBNP and ADO index were compared between the two groups.Logistic regression analysis was used to analyze the risk factors affecting survival of patients,and log-rank test was used to compare the survival rate between groups.Results:After 2 years of followup,there were 25 deaths(23.58%).The course of disease,plasma TWEAK and NT-proBNP levels and ADO index scores were significantly higher in death group than that in survival group,with statistically significant differences(P<0.05).Mortality rates of patients with high expression of plasma TWEAK and NT-proBNP were significantly higher than that of low expression group,and the mortality rate of patients with high ADO index score was significantly higher than that of the low score group(P<0.05).Pearson correlation analysis showed that there was a positive correlation between levels of NT-proBNP,TWEAK and ADO index scores(r=0.613,0.684;P<0.001).Logistic regression analysis showed that disease course,plasma TWEAK and NT-proBNP levels and ADO index scores were independent risk factors for survival in COPD patients(P<0.05).Conclusion:Expressions of TWEAK,NT-proBNP and ADO index are independent risk factors for the survival in COPD patients.The higher level of each indicator,the higher risk of death.