急性脑梗死患者血清同型半胱氨酸、纤维蛋白原和胱抑素C的水平分析及其与病情严重程度的关系

Analysis of Serum Homocysteine,Fibrinogen and Cystatin C Levels in Patients with Acute Cerebral Infarction and Their Relationship with the Severity of the Disease

目的:分析急性脑梗死患者血清同型半胱氨酸、纤维蛋白原和胱抑素C水平及其与病情严重程度的关系。方法:选取2018年1月-2020年1月本院收治的急性脑梗死患者120例作为研究组,另选取同时期80例正常体检人群作为对照组,对两组临床资料均进行回顾性分析。比较两组血清同型半胱氨酸、纤维蛋白原和胱抑素C水平。研究组根据入院时美国国立卫生研究院卒中量表(national institute of health stroke scale,NIHSS)评分分为轻度组(1分≤NIHSS评分<5分)、中度组(5分≤NIHSS评分<15分)、中-重度组(15分≤NIHSS评分<21分)、重度组(21分≤NIHSS评分≤42分),分析不同病情严重程度患者的血清指标水平差异及其与病情严重程度之间的关系。结果:研究组血清同型半胱氨酸、纤维蛋白原和胱抑素C水平均高于对照组(P<0.05)。按照入院时的NIHSS评分,120例急性脑梗死患者分为轻度组65例、中度组26例、中-重度组15例、重度组14例,不同病情严重程度患者的血清同型半胱氨酸、纤维蛋白原和胱抑素C水平比较,差异均有统计学意义(P<0.05),且轻度组<中度组<中-重度组<重度组(P<0.05)。经过Spearman相关性分析发现,血清同型半胱氨酸、纤维蛋白原和胱抑素C水平与急性脑梗死患者的病情严重程度均呈正相关(P<0.05)。结论:血清同型半胱氨酸、纤维蛋白原和胱抑素C参与了急性脑梗死的病情发展过程,其与病情严重程度均呈正相关。在一定程度上,上述指标水平反映了患者神经功能缺损的严重程度,临床上关注血清同型半胱氨酸、纤维蛋白原和胱抑素C水平,对于疾病的监测、治疗及预后评估均有一定的指导意义。

Objective:To analyze the levels of serum homocysteine,fibrinogen and cystatin C in patients with acute cerebral infarction and their relationship with the severity of the disease.Method:A total of 120 patients with acute cerebral infarction admitted to our hospital from January 2018 to January 2020 were selected as the study group,and another 80 patients with normal physical examination during the same period were selected as the control group.Clinical data of the two groups were retrospectively analyzed.Serum levels of homocysteine,fibrinogen and cystatin C were compared between the two groups.The study group according to the national institute of health stroke scale(NIHSS)score at admission was divided into mild group(1 score≤NIHSS<5 scores),moderate group(5 scores≤NIHSS<15 scores),moderate-severe group(15 scores≤NIHSS<21 scores)and severe group(21 scores≤NIHSS≤42 scores).The differences of serum indexes in patients with different disease severity and their relationship with disease severity were analyzed.Result:Serum homocysteine,fibrinogen and cystatin C levels in the study group were higher than those in the control group(P<0.05).According to the NIHSS score on admission to hospital,120 patients with acute cerebral infarction were divided into mild group of 65 cases,moderate group of 26 cases,15 cases of moderate-severe group,14 cases of severe group.There were statistically significant differences in serum homocysteine,fibrinogen and cystatin C levels among patients with different severity of the disease(P<0.05),and mild group<moderate group<moderate-severe group<severe group(P<0.05).Spearman correlation analysis showed that serum levels of homocysteine,fibrinogen and cystatin C were positively correlated with the severity of acute cerebral infarction(P<0.05).Conclusion:Serum homocysteine,fibrinogen and cystatin C involve in the development process of acute cerebral infarction,and are positively correlated with the severity of the disease.To a certain extent,the levels of these indicators reflect the severity of the patient’s neurological impairment.In clinical practice,it is of certain guiding significance to pay attention to the levels of serum homocysteine,fibrinogen and cystatin C for the monitoring,treatment and prognosis evaluation of the disease.