屈螺酮炔雌醇对人工流产术后子宫内膜恢复及术后并发症的影响

Effect of Drospirenone Ethinylestradiol on Endometrial Recovery and Postoperative Complications after Abortion

目的:探讨屈螺酮炔雌醇片(Ⅱ)(商品名:优思悦)对人工流产术后子宫内膜恢复及术后并发症的影响。方法:选取2018年4月-2019年12月在本院进行人工流产手术的90例患者,按照随机数字表法分为观察组和对照组,每组45例。两组人工流产术后当日给予甲硝唑片,新生化颗粒服用时间为1周;观察组在以上给药方案基础上给予屈螺酮炔雌醇片(Ⅱ),对照组给予安慰剂,服用时间均为1个月。比较两组术后恢复情况、并发症发生情况、治疗前后子宫血流动力学指标。结果:观察组阴道流血时间明显短于对照组,阴道流血量明显少于对照组,月经恢复时间明显早于对照组,术后3周子宫内膜厚度明显厚于对照组,差异均有统计学意义(P<0.05)。观察组术后并发症发生率明显低于对照组(P<0.05)。治疗后,两组子宫动脉搏动指数、阻力指数均低于治疗前(P<0.05),两组血流量、血流峰值速度均显著高于治疗前(P<0.05),观察组子宫动脉搏动指数、阻力指数均显著低于对照组(P<0.05),血流量、血流峰值速度均显著高于对照组(P<0.05)。结论:屈螺酮炔雌醇能够通过影响子宫血流动力学相关指标,有效促进人工流产术后子宫内膜的恢复,安全性较高。

Objective:To explore the effect of Drospirenone Ethinylestradiol Tabels(Ⅱ)(trade name:Yousiyue)on endometrial recovery and postoperative complications after induced abortion.Method:A total of 90 patients who underwent induced abortion in our hospital from April 2018 to December 2019 were selected,they were randomly divided into observation group and control group,45 cases in each group.The two groups were given Metronidazole Tablets on the day after artificial abortion,and the New Biochemical Granules were taken for 1 week.Observation group based on the above dosage regimen for Drospirenone Ethinylestradiol Tabels(Ⅱ),the control group given a placebo,taking time for 1 month.Result:The duration of vaginal bleeding in the observation group was significantly shorter than that in the control group,the amount of vaginal bleeding was significantly less than that in the control group,the menstrual recovery time was significantly earlier than that in the control group,the endometrial thickness was significantly thicker 3 weeks after operation than that in the control group,the differences were statistical significance(P<0.05).The incidence of postoperative complications in the observation group was significantly lower than that in the control group(P<0.05).After treatment,two groups of uterine artery pulsation index and resistance index were lower than before treatment(P<0.05),two groups of blood flow,blood flow peak velocity were significantly higher than before treatment(P<0.05),uterine artery pulsation index and resistance index in the observation group were significantly lower than those of the control group(P<0.05),blood flow,blood flow peak velocity were significantly higher than those of the control group(P<0.05).Conclusion:Drospirenone Ethinylestradiol can effectively promote the recovery of endometrium after induced abortion by influencing uterine hemodynamic indexes,it is safe.