高压氧联合负压封闭引流术治疗口腔颌面部间隙感染的效果观察

Effect of Hyperbaric Oxygen Combined with Vacuum Sealing Drainage onOral and Maxillofacial Space Infection

目的:研究高压氧联合负压封闭引流术治疗口腔颌面部间隙感染的效果。方法:选择2017年12月~2019年12月于遂宁市中心医院(我院)的100例口腔颌面部间隙感染患者,将其随机分为两组。对照组的50例口腔颌面部间隙感染患者在常规清创后采用负压封闭引流术,观察组的50例口腔颌面部间隙感染患者在负压封闭引流术的基础上联用高压氧疗法。检测两组的超敏C反应蛋白(High sensitivity C-reactive protein,hs-CRP)、降钙素原(Procalcitonin,PCT)和白细胞(White blood cell,WBC)计数水平;并记录两组的伤口愈合时间、住院时间和肉芽组织生长时间。结果:观察组口腔颌面部间隙感染患者的有效率明显高于对照组(P<0.05);治疗后,两组的血清hs-CRP、PCT和WBC水平均明显降低(P<0.05),且观察组的血清hs-CRP、PCT和WBC水平明显低于对照组(P<0.05);观察组口腔颌面部间隙感染患者的伤口愈合时间、住院时间和肉芽组织生长时间均明显短于对照组(P<0.05)。结论:高压氧联合负压封闭引流术能明显降低口腔颌面部间隙感染患者的血清hs-CRP、PCT和WBC水平,加快创腔创面肉芽组织的生长速度,提高疗效,值得进行推广。

Objective: To investigate the effect of hyperbaric oxygen combined with vacuum sealing drainage in the treatment of oral and maxillofacial space infection. Methods: A total of 100 patients with oral and maxillofacial space infection, who were treated in Suining Central Hospital from December 2017 to December 2019, were selected and were randomly and equally divided into two groups.The control group was treated with vacuum sealing drainage after conventional debridement, and the observation group was treated with hyperbaric oxygen therapy on the basis of vacuum sealing drainage. The levels of hs-CRP, PCT and WBC were detected, and the wound healing time, hospitalization time and granulation tissue growth time of the two groups were recorded. Results: The effective rate of the observation group was significantly higher than that of the control group(P<0.05). After treatment, the serum hs-CRP, PCT and WBC levels of the two groups were significantly reduced(P<0.05), and the serum hs-CRP, PCT and WBC levels of the observation group were significantly lower than those of the control group(P<0.05). The wound healing time, hospitalization time and granulation tissue growth time of patients with oral and maxillofacial space infection in the observation group were significantly shorter than those in the control group(P<0.05). Conclusions: Hyperbaric oxygen combined with vacuum sealing drainage can significantly reduce the levels of serum hs CRP, PCT and WBC in patients with oral and maxillofacial space infection, accelerate the growth rate of granulation tissue in wound cavity and improve the curative effect, which is worthy of promotion.