继发性肺结核伴呼吸衰竭患者肺功能与血气指标的相关性

Correlation between Lung Function and Blood Gas Indexes in Patients withSecondary Tuberculosis Combined with Respiratory Failure

目的:探讨继发性肺结核伴呼吸衰竭患者肺功能与血气指标的相关性。方法:2018年3月到2020年1月选择在本院诊治的继发性肺结核患者122例,所有患者都给予肺功能与血气指标检测,并进行相关性分析。结果:122例患者根据合并呼吸衰竭情况分为呼吸衰竭组(n=48)与非呼吸衰竭组(n=74)。呼吸衰竭组的用力肺活量(Forced vital capacity,FVC)、第一秒用力肺活量(forced expiratory volume in one second,FEV1)、FEV1/FVC、MMEF、MEF50、MEF25值都显著低于非呼吸衰竭组(P<0.05);呼吸衰竭组的PaO_(2)与Hb值显著低于非呼吸衰竭组(P<0.05),两组PaCO_(2)、pH值对比差异无统计学意义(P>0.05);呼吸衰竭组的低氧血症、高血红蛋白血症等发生率显著高于非呼吸衰竭组(P<0.05),两组高碳酸血症发生率对比差异无统计学意义(P>0.05)。在呼吸衰竭组中,Spearman相关性检验分析显示FVC、FEV1、FEV1/FVC、MMEF、MEF50、MEF25与PaO_(2)、Hb存在相关性(P<0.05)。结论:继发性肺结核伴呼吸衰竭患者在临床上比较常见,多伴随有肺功能下降与血气指标异常,呼吸衰竭患者的肺功能与血气指标存在相关性。

Objective: To investigate the correlation between lung function and blood gas indexes in patients with secondary tuberculosis combined with respiratory failure. Methods: A total of 122 patients with secondary pulmonary tuberculosis, who were diagnosed and treated in Affiliated Hospital of Hebei University from March 2018 to January 2020, were chosen as the research subjects and were divided into respiratory failure group(n=48) and non-respiratory failure group(n=74). All the patients were detected for lung function and blood gas indicators, which were given correlation analysis. Results: The values of FVC, FEV1, FEV1/FVC, MMEF, MEF50 and MEF25 in the respiratory failure group were significantly lower than those in the non-respiratory failure group(P<0.05). The PaO2 and Hb values in the respiratory failure group were significantly lower than those in the non-respiratory failure group(P<0.05), there were no significant difference in PaCO2 and pH between the two groups(P>0.05). The incidence of hypoxemia and hyperhemoglobinemia in the respiratory failure group were significantly higher than that in the non-respiratory failure group(P<0.05). There was no significant difference in the incidence of hypercapnia compared between the two groups(P>0.05). In the respiratory failure group, Spearman correlation analysis showed that FVC, FEV1, FEV1/FVC, MMEF, MEF50, MEF25 were correlated with PaO2 and Hb(P<0.05). Conclusion: Patients with secondary pulmonary tuberculosis combined with respiratory failure are more common clinically, and are usually accompanied by decreased lung function and abnormal blood gas indicators. There is correlation between lung function and blood gas indicators in patients with respiratory failure.