鱼肝油酸钠联合普萘洛尔对肝硬化消化道出血的疗效及对应激反应的影响

Effect of Sodium Morrhuate Sodium and Propranolol in Treatment of Liver Cirrhosis with Gastrointestinal Hemorrhage and Its Effect on Stress Response

目的:研究鱼肝油酸钠联合普萘洛尔对肝硬化消化道出血的疗效及对应激反应的影响。方法:选取2016年9月至2017年8月我院收治的83例肝硬化消化道出血患者,根据患者入院顺序先后分为观察组(n=43例)和对照组(n=40例)。对照组使用鱼肝油酸钠注射液,观察组联合普萘洛尔片。比较两组患者临床疗效,丙二醛(MDA)、超氧化物歧化酶(SOD)、血清胆碱酯酶水平,临床症状改善情况,止血和半年内再出血情况,不良反应。结果:治疗后,观察组临床有效率显著高于对照组(P<0.05)。治疗前,两组患者MDA、SOD、胆碱酯酶水平比较著差异(P>0.05),治疗后,观察组的MDA水平低于对照组(P<0.05),SOD、胆碱酯酶水平高于对照组(P<0.05)。治疗前,两组患者心率、静脉压比较无差异(P>0.05),治疗后,观察组的心率低于对照组(P<0.05),静脉压高于对照组(P<0.05)。观察组的止血时间和再出血率少于对照组(P<0.05)。观察组的不良反应率低于对照组(P<0.05)。结论:鱼肝油酸钠联合普萘洛尔能有效改善肝硬化消化道出血患者的应激反应和临床症状,临床疗效良好,安全性高。

Objective: To study the effect of sodium morrhuate combined with propranolol on cirrhosis of gastrointestinal bleeding and its effect on stress response. Methods: Eighty-three patients with cirrhosis and gastrointestinal hemorrhage who were admitted to our hospital from September 2016 to August 2017 were selected, and divided into observation group(n=43) and control group(n=40) according to the order of admission. The control group used sodium morrhuate injection, and the observation group combined with propranolol tablets. Comparing the clinical efficacy of two groups of patients, malondialdehyde(MDA), superoxide dismutase(SOD), serum cholinesterase levels, improvement of clinical symptoms, hemostasis and re-bleeding within six months, adverse reactions. Results: After treatment, the clinical effectiveness of the observation group was higher than the control group(P<0.05). Before treatment, there was no significant difference in MDA, SOD and cholinesterase levels between the two groups(P>0.05). After treatment, the MDA level in the observation group was lower than the control group(P<0.05). The level of SOD, cholinesterase was higher than the control group(P<0.05).Before treatment, there was no significant difference in heart rate and venous pressure between the two groups(P>0.05). After treatment,the heart rate of the observation group was lower than the control group(P<0.05), and the venous pressure was higher than the control group(P<0.05). The hemostatic time and rebleeding rate in the observation group wer less than those in the control group(P<0.05). The adverse reaction rate in the observation group was lower than the control group(P<0.05). Conclusion: The combination of sodium morrhuate and propranolol can effectively improve the stress response and clinical symptoms of patients with cirrhosis and gastrointestinal bleeding. The clinical efficacy is good and the safety is high.