冻融胚胎移植对子代的近、远期影响

Short-and long-term effects of frozen-thawed embryo transfer on offspring

冻融胚胎移植(frozen-thawed embryo transfer,FET)是常用辅助生殖技术之一。由于FET具有累积妊娠率高、卵巢过度刺激综合征发生率低等优势,通过该项技术出生的子代数量逐年增加。多项研究提示FET子代发生围产期早产、低出生体质量、小于胎龄儿等的风险低于新鲜胚胎移植周期出生的子代,也有证据显示FET子代出现巨大儿、大于胎龄儿等的风险较高;同时,亦有研究针对FET子代在儿童期及成人期的长期健康状况进行报道。该文就FET对子代的近、远期影响及其原因进行综述。

Frozen-thawed embryo transfer(FET)is one of the commonly used assisted reproductive technology.Because FET has the advantages of high cumulative pregnancy rate and low incidence of ovarian hyperstimulation syndrome,the number of offspring born through this technology is increasing year by year.Many studies have shown that the risks of preterm delivery,low birth weight and small for gestation age of FET offspring are lower than those of the offspring born in the fresh embryo transfer cycle.There is also evidence that the risks of macrosomia and large for gestational age of FET offspring are higher.At the same time,there are also reports on the long-term health status of FET offspring in childhood and adulthood.This paper reviews the short-term and long-term effects of FET on offspring and the causes.