肺炎支原体感染儿童凝血功能的变化分析及其临床意义

Analysis of Changes in Coagulation Function in Children Infected with Mycoplasma Pneumoniae and Its Clinical Significance

目的探讨肺炎支原体感染儿童凝血功能的变化及其临床意义。方法应用病例对照研究方法,将2015年1月—2018年12月常熟市第一人民医院收治的203例肺炎支原体感染儿童作为实验组,其中5 Au/mL<MP-IgM滴度≤15 Au/mL为低滴度组,共90例;MP-IgM滴度为>15 Au/mL为高滴度组,共113例;另外选取120名同期在该院门诊做健康体检的儿童为对照组,测定3组儿童凝血功能4项及血浆D-二聚体定量指标。结果实验组患儿凝血酶原时间(PT)(11.75±0.88)s较对照组(12.15±1.18)s缩短,差异有统计学意义(t=3.060,P<0.05);实验组患儿活化部分凝血酶原时间(APTT)(31.16±5.48)s较对照组(33.20±3.32)s缩短,差异有统计学意义(t=3.510,P<0.05);实验组患儿纤维蛋白原(FIB)定量(4.02±0.92)g/L较对照组(3.07±0.48)g/L高,差异有统计学意义(t=10.120,P<0.05);实验组患儿D-二聚体定量(0.79±0.60)mg/L较对照组(0.43±0.30)mg/L高,差异有统计学意义(t=5.850,P<0.05);高滴度组患儿PT(11.66±0.85)s、APTT(31.18±6.65)s较对照组明显缩短,差异有统计学意义(P<0.05);低滴度组患儿APTT(31.14±3.77)s较对照组缩短,差异有统计学意义(P<0.05);高滴度组和低滴度组患儿FIB定量分别为(4.11±1.15)g/L、(3.90±0.74)g/L,D-二聚体定量分别为(0.72±0.37)mg/L、(0.86±0.77)mg/L均较对照组高,差异有统计学意义(P<0.05)。结论肺炎支原体感染有潜在激活机体凝血系统,导致凝血功能异常,重者容易发生血栓。

Objective To investigate the changes of coagulation function in children infected with Mycoplasma pneumoniae and its clinical significance.Methods Using the case-control study method,203 children with Mycoplasma pneumoniae infection who were admitted to Changshu First People’s Hospital from January 2015 to December 2018 were taken as the experimental group,and 5 Au/mL<the MP-IgM titer≤15 Au/mL was low titer group,90 cases;MP-IgM titer of>15 Au/mL,high titer group,113 cases.In addition,120 children who had a health checkup in the outpatient clinic of the hospital during the same period were selected as the control group,and the three groups were determined.Determination of four items of coagulation function and plasma D-dimer quantitative index in three groups of children.Results The prothrombin time(PT)(11.75±0.88)s of the experimental group of children was shorter than that of the control group(12.15±1.18)s,and the difference was statistically significant(t=3.060,P<0.05);children in the experimental group activated partial prothrombin time(APTT)(31.16±5.48)s was shorter than that of the control group(33.20±3.32)s,and the difference was statistically significant(t=3.510,P<0.05);the fibrinogen(FIB)of children in the experimental group was quantitatively(4.02±0.92)g/L was higher than that of the control group(3.07±0.48)g/L,and the difference was statistically significant(t=10.120,P<0.05);the amount of D-dimer in children in the experimental group was(0.79±0.60)mg/L was higher than that of the control group(0.43±0.30)mg/L,and the difference was statistically significant(t=5.850,P<0.05);children in the high titer group had PT(11.66±0.85)s and APTT(31.18±6.65)s compared with the control was significantly shorter,and the difference was statistically significant(P<0.05);the APTT(31.14±3.77)s of children in the low-titer group was shorter than that of the control group,and the difference was statistically significant(P<0.05);the quantitative FIB of children in the high-titer group and low-titer group were(4.11±1.15)g/L and(3.90±0.74)g/L,respectively,and the quantitative D-dimer was(0.72±0.37)mg/L,(0.86±0.77)mg/L were higher than those of the control group,and the difference was statistically significant(P<0.05).Conclusion Mycoplasma pneumoniae infection has the potential to activate the body's coagulation system,leading to abnormal coagulation function,and thrombosis in severe cases.