抗利尿激素联合肾上腺素治疗急诊心脏骤停的效果探析

Analysis of the Effect of Antidiuretic Hormone Gombined with Epinephrine in the Treatment of Emergency Cardiac Arrest

目的探讨抗利尿激素+肾上腺素治疗急诊心脏骤停的效果。方法选取2017年7月—2019年9月该院收治的116例急诊心脏骤停患者,按照随机数字抽取分成观察组(n=58)与对照组(n=58),对照组采取肾上腺素治疗,观察组采用抗利尿激素联合肾上腺素治疗,观察两组患者自主循环恢复率与恢复时间、自主呼吸恢复率与恢复时间、>1 d存活率、出急诊室率、格拉斯哥昏迷指数量表(GCS)评分、格拉斯哥-匹兹堡脑功能表现分类(CPC)评分。结果观察组患者自主循环恢复时间为(9.52±1.26)min、自主呼吸恢复时间为(85.21±2.63)min均短于对照组(15.92±1.32)min、(86.57±2.69)min,差异有统计学意义(t=26.710、2.753,P<0.05);GCS评分(11.76±1.58)分,高于对照组(9.15±1.46)分,差异有统计学意义(t=9.240,P<0.05);观察组患者自主循环恢复率82.76%、自主呼吸恢复率62.07%、>1 d存活51.72%、出急诊室率34.48%,对照组自主循环恢复率51.72%、自主呼吸恢复率34.48%、>1 d存活31.03%、出急诊室率17.24%,观察组均高于对照组,差异有统计学意义(χ^(2)=12.680、8.838、5.118、4.277,P<0.05);两组患者CPC 3~5分差异有统计学意义(χ^(2)=7.003,P=0.008)。结论抗利尿激素+肾上腺素治疗急诊心脏骤停的效果显著,可促进患者恢复,提高存活率,应用价值高。

Objective To explore the effect of antidiuretic hormone+epinephrine in the treatment of emergency cardiac arrest.Methods A total of 116 patients with emergency cardiac arrest admitted to the hospital from July 2017 to September 2019 were randomly selected and divided into observation group(n=58)and control group(n=58).The control group took adrenaline treatment,the observation group was treated with antidiuretic hormone combined with epinephrine,and the spontaneous circulation recovery rate and recovery time,spontaneous breathing recovery rate and recovery time,>1 d survival rate,emergency room rate,Glasgow Coma Index Scale(GCS)score,Glasgow-Pittsburgh Brain Function Classification(CPC)score were observed in the two groups.Results The recovery time of spontaneous circulation in the observation group was(9.52±1.26)min,and the recovery time of spontaneous breathing was(85.21±2.63)min,which were shorter than those in the control group(15.92±1.32)min and(86.57±2.69)min,the difference were statistically significant(t=26.710,2.753,P<0.05);GCS score(11.76±1.58)points,higher than the control group(9.15±1.46)points,the difference were statistically significant(t=9.240,P<0.05);observation group patients spontaneous circulation recovery rate 82.76%,spontaneous breathing recovery rate was 62.07%,>1 d survival rate was 51.72%,emergency room rate was 34.48%,control group spontaneous circulation recovery rate was 51.72%,spontaneous breathing recovery rate was 34.48%,>1 d survival rate was 31.03%,and emergency room rate was 17.24%,the observation group was higher than the control group,the difference were statistically significant(χ^(2)=12.680,8.838,5.118,4.277,P<0.05);there were significant differences in CPC 3-5 scores between the two groups(χ^(2)=7.003,P=0.008).Conclusion Antidiuretic hormone+epinephrine has a significant effect on the treatment of emergency cardiac arrest,which can promote the recovery of patients,improve the survival rate,and has high application value.