锝[^(99)Tc]亚甲基二膦酸盐治疗老年女性绝经后骨质疏松症的疗效和安全性分析

Analysis of the Efficacy and Safety of Technetium[^(99)Tc]methylene Bisph-osphonate in the Treatment of Postmenopausal Osteoporosis in Elderly Women

目的分析锝[^(99)Tc]亚甲基二膦酸盐治疗老年女性绝经后骨质疏松症的疗效和安全性。方法选取2017年1月—2019年12月的绝经后骨质疏松症老年女性患者60例,以随机的方式分成对照组30例,观察组30例,对照组给予常规治疗,应用维生素D钙咀嚼片治疗,观察组在常规治疗同时应用锝[^(99)Tc]亚甲基二膦酸盐治疗。比较两组的临床疗效和安全性。结果在治疗的总有效率方面,观察组为93.33%,明显高于对照组的73.33%,差异有统计学意义(χ^(2)=4.320,P<0.05)。治疗后,观察组的骨密度(BMD)、血清骨钙素(BGP)和骨碱性磷酸酶(BALP)的改善程度优于对照组,差异有统计学意义(P<0.05)。在安全性方面,观察组与对照组的不良反应发生率分别是6.66%与3.33%,差异无统计学意义(χ^(2)=0.351,P>0.05)。结论锝[^(99)Tc]亚甲基二膦酸盐治疗老年女性绝经后骨质疏松症的疗效显著,应用安全,推荐在临床中广泛的应用。

Objective To analyze the efficacy and safety of technetium[^(99)Tc]-methylene bisphosphonate in the treatment of postmenopausal osteoporosis in elderly women.Methods Sixty elderly female patients with postmenopausal osteoporosis from January 2017 to December 2019 were enrolled.They were randomly divided into a control group of 30 cases and an observation group of 30 cases.The control group was given conventional treatment and vitamin D calcium chewing tablet therapy,the observation group was treated with technetium[^(99)Tc]-methylene bisphosphonate at the same time as conventional treatment.The clinical efficacy and safety of the two groups were compared.Results In terms of the total effective rate of treatment,the observation group was 93.33%,which was significantly higher than the control group's 73.33%,and the difference was statistically significant(χ^(2)=4.320,P<0.05).After treatment,the improvement of bone mineral density(BMD),serum osteocalcin(BGP)and bone alkaline phosphatase(BALP)of the observation group was better than that of the control group,and the difference were statistically significant(P<0.05).In terms of safety,the incidence of adverse reactions in the observation group and the control group were 6.66%and 3.33%,respectively,and the difference were not statistically significant(χ^(2)=0.351,P>0.05).Conclusion Technetium[^(99)Tc]methylene bisphosphonate is effective in treating postmenopausal osteoporosis in elderly women,and it is safe to use.It is recommended to be widely used in clinical practice.