前列腺特异性抗原在老年前列腺疾病诊断中的应用研究

Application of Prostate Specific Antigen in the Diagnosis of Elderly Prostate Diseases

目的分析老年前列腺疾病诊断中前列腺特异性抗原(prostate specific antigen,PSA)的应用价值。方法选取90例该院2019年1月—2020年1月期间收治的老年前列腺疾病患者为研究组,根据其病理或穿刺活检结果分为前列腺增生组50例,前列腺癌组40例,另选取同期该院接受健康体检者40名为对照组,采集所有研究对象晨起空腹肘静脉血,对其fPSA、tPSA含量进行测定。结果前列腺癌组fPSA为(2.14±0.98)ng/mL,tPSA为(54.68±7.95)ng/mL,高于前列腺增生组患者的(0.75±0.36)、(9.35±4.16)ng/mL,差异有统计学意义(t=9.287、34.827,P<0.05)。以病理和穿刺活检结果为诊断标准,fPSA、tPSA联合诊断老年前列腺疾病的准确率为92.78%,敏感度为93.42%,特异度为96.38%,AUC值为0.946,均优于单独fPSA或tPSA检测,差异有统计学意义(P<0.05)。结论在老年前列腺疾病诊断中,联合应用fPSA、tPSA等前列腺特异性抗原相关指标检测,能够有效提升临床对老年前列腺疾病的诊断准确率,从而准确鉴别老年前列腺癌和良性前列腺增生,为临床治疗方案制定提供更有价值的参考信息。

Objective To analyze the application value of prostate specific antigen(PSA)in the diagnosis of elderly prostate diseases.Methods 90 cases of elderly patients with prostate disease admitted to the hospital from January 2019 to January 2020 were selected as the research group.According to their pathology or biopsy results,they were divided into 50 cases of prostate hyperplasia group and 40 cases of prostate cancer group.During the same period,40 cases in the hospital underwent health checkup as the control group.All subjects were collected in the morning fasting cubital venous blood,and their fPSA and tPSA contents were determined.Results The fPSA of the prostate cancer group was(2.14±0.98)ng/mL,and the tPSA was(54.68±7.95)ng/mL,which was higher than the(0.75±0.36)ng/mL and(9.35±4.16)ng/mL of the prostate hyperplasia group.The difference was statistically significant(t=9.287,34.827,P<0.05).Taking pathology and biopsy results as the diagnostic criteria,the accuracy of fPSA and tPSA combined in the diagnosis of elderly prostate diseases was 92.78%,the sensitivity was 93.42%,the specificity was 96.38%,and the AUC value was 0.946,which were better than those of fPSA or tPSA alone,the difference was statistically significant(P<0.05).Conclusion In the diagnosis of elderly prostate diseases,the combined application of fPSA,tPSA and other prostate-specific antigen-related indicators can effectively improve the clinical diagnosis accuracy of elderly prostate diseases,thereby accurately distinguishing elderly prostate cancer and benign prostatic hyperplasia,provide more valuable reference information for clinical treatment formulation.