稳心颗粒联合胺碘酮治疗心房颤动临床研究

Clinical Study on Wenxin Granules Combined with Amiodarone for Atrial Fibrillation

目的:观察稳心颗粒联合胺碘酮治疗心房颤动(AF)的临床疗效。方法:选取72例AF患者,根据入院编号顺序随机分为对照组和研究组,每组36例。对照组给予胺碘酮治疗,研究组在对照组治疗基础上加用稳心颗粒,2组均治疗2个月。比较2组临床疗效及左心房重构指标。结果:治疗后,研究组总有效率为91.67%,高于对照组的75.00%(P<0.05)。治疗后,2组左心室舒张早期二尖瓣血流峰值(E)、左心房收缩时二尖瓣血流峰值(A)、E/A值均较治疗前增大(P<0.05),研究组E、A、E/A值均大于对照组(P<0.05);2组左心房直径均较治疗前缩小(P<0.05),研究组左心房直径小于对照组(P<0.05)。结论:稳心颗粒联合胺碘酮治疗AF,可改善患者左心房重构指标,提高临床疗效。

Objective:To observe the clinical effect of Wenxin granules combined with amiodarone on atrial fibrillation(AF).Methods:A total of 72 AF patients were selected and randomly divided into the control group and the study group according to the order of admission number, 36 patients in each group. The control group was treated with amiodarone,and the study group was additionally treated with Wenxin granules based on the treatment of the control group. Both groups were treated for two months. The clinical effect and indexes of left atrial remodeling were compared between the two groups. Results:After treatment,the total effective rate was 91.67% in the study group,higher than that of 75.00% in the control group(P<0.05).After treatment,peak velocity blood flow from left ventricular relaxation in early diastole(E),peak velocity flow in late diastole caused by atrial contraction(A),and the E/A ratio were increased in both groups when compared with those before treatment(P<0.05);the levels of E,A and E/A ratio in the study group were higher than those in the control group(P<0.05).The diameter of the left atrium in both groups was respectively smaller than that before treatment(P<0.05),and the one in the study group was smaller than that in the control group(P<0.05). Conclusion:The therapy of Wenxin granules combined with amiodarone for patients with AF can improve the indexes of left atrial remodeling and the clinical effect.