舒血宁注射液联合丹参滴丸对急性冠脉综合征患者血脂和心功能的影响

Effect of Shuxuening Injection Combined with Danshen Dropping Pill on Blood Lipid and Heart Function in Patients with Acute Coronary Syndrome

目的:探讨舒血宁注射液联合丹参滴丸对急性冠脉综合征(ACS)患者血脂和心功能的影响。方法:选取2015年2月~2019年12月期间我院收治的ACS患者90例,按照随机数字表法将上述患者分为对照组(n=45,常规基础治疗)和研究组(n=45,增加舒血宁注射液联合丹参滴丸治疗),比较两组患者疗效、血脂、心功能及不良反应。结果:研究组治疗2个疗程后的临床总有效率为91.11%(41/45),高于对照组的73.33%(33/45)(P<0.05)。两组治疗2个疗程后总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、甘油三酯(TG)均较治疗前降低,且研究组低于对照组(P<0.05);高密度脂蛋白胆固醇(HDL-C)较治疗前升高,且研究组高于对照组(P<0.05)。两组治疗2个疗程后左心室射血分数(LVEF)、心脏指数(CI)、心排血量(CO)均较治疗前升高,且研究组高于对照组(P<0.05);左室舒张末期内径(LVEDD)较治疗前降低,且研究组低于对照组(P<0.05)。两组治疗期间不良反应发生率比较差异无统计学意义(P>0.05)。结论:舒血宁注射液联合丹参滴丸治疗ACS,疗效显著,可有效改善患者血脂及心功能,且不增加不良反应发生率,安全可靠。

Objective:To investigate the effect of Shuxuening injection combined with Danshen dropping pill on blood lipid and heart function in patients with acute coronary syndrome(ACS).Methods:90 patients with ACS who were admitted to our hospital from February 2015 to December 2019 were selected,patients were randomly divided into the control group(n=45,routine basic treatment)and the study group(n=45,treatment of increasing Shuxuening injection combined with Danshen dropping pill)according to the digital table method.The curative effect,blood lipid,cardiac function and adverse reactions of the two groups were compared.Results:The total effective rate of the study group at 2 courses after treatment was 91.11%(41/45),which was higher than 73.33%(33/45)of the control group(P<0.05).The total cholesterol(TC),low-density lipoprotein cholesterol(LDL-C)and triglyceride(TG)of the two groups at 2 courses after treatment were lower than those before treatment,and the study group was lower than the control group(P<0.05).The high-density lipoprotein cholesterol(HDL-C)was higher than that before treatment,and the study group was higher than the control group(P<0.05).The left ventricular ejection fraction(LVEF),cardiac index(CI)and cardiac output(CO)of the two groups at 2 courses after treatment were higher than those before treatment,and the study group was higher than the control group(P<0.05),and the left ventricular end diastolic diameter(LVEDD)was lower than before treatment,and the study group was lower the control group(P<0.05).There was no significant difference in adverse reactions between the two groups(P>0.05).Conclusion:Shuxuening injection combined with Danshen dropping pill is effective in the treatment of ACS.It can effectively improve the blood lipid and heart function of the patients without increasing the incidence of adverse reactions.It is safe and reliable.