甲基强的松龙联合神经节苷脂治疗急性脊髓炎的疗效

Efficacy of Methylprednisolone Combined with Ganglioside in the Treatment of Acute Myelitis

目的研究甲基强的松龙联合神经节苷脂治疗急性脊髓炎的临床效果。方法选取2019年11月~2020年11月我院治疗的94例急性脊髓炎患者为研究对象,采用随机数字表法分为对照组和观察组,各47例。对照组采用甲基强的松龙治疗,观察组在对照组基础上联合神经节苷脂治疗,比较两组临床治疗疗效、运动和感觉功能评分、独立行走时间、肢体肌肉恢复二级以上时间、排尿恢复时间、括约肌功能恢复时间以及临床不良反应发生情况。结果观察组治疗总有效率的93.61%,高于对照组的80.85%,差异有统计学意义(P<0.05);观察组运动、感觉功能评分高于对照组,差异有统计学意义(P<0.05);观察组独立行走、肢体肌肉恢复二级以上、排尿恢复及括约肌功能恢复时间短于对照组,差异有统计学意义(P<0.05);观察组不良反应发生率为6.38%,与对照组的8.51%比较,差异无统计学意义(P>0.05)。结论甲基强的松龙联合神经节苷脂治疗急性脊髓炎效果确切,可促进患者感觉和运动功能恢复,缩短肢体肌肉、排尿、括约肌功能恢复以及排尿时间,且临床不良反应少,应用安全性良好。

Objective To study the clinical effect of methylprednisolone combined with ganglioside in the treatment of acute myelitis.Methods 94 patients with acute myelitis treated in our hospital from November 2019 to November 2020 were selected as the research objects,and they were divided into control group and observation group by random number table method,with 47 cases in each group.The control group was treated with methylprednisolone,and the observation group was treated with ganglioside on the basis of the control group.The clinical treatment efficacy,motor and sensory function scores,independent walking time,limb muscle recovery time above level 2,urination recovery time,sphincter function recovery time,and clinical adverse reactions were compared between the two groups.Results The total effective rate of treatment in the observation group was 93.61%,which was higher than 80.85%in the control group,the difference was statistically significant(P<0.05);The motor and sensory function scores of the observation group were higher than those of the control group,the difference was statistically significant(P<0.05);The observation group walked independently,the limb muscle recovery was above grade two,urination recovery and sphincter function recovery time were shorter than those of the control group,the difference was statistically significant(P<0.05);The incidence of adverse reactions in the observation group was 6.38%,compared with 8.51%in the control group,the difference was not statistically significant(P>0.05).Conclusion Methylprednisolone combined with ganglioside is effective in the treatment of acute myelitis.It can promote the recovery of sensory and motor function of patients,shorten the recovery of limb muscles,urination,sphincter function and urination time,and has fewer clinical adverse reactions and is safe to use good.