甲状腺相关性眼病氧化应激反应的研究进展

Advances on the oxidative stress and thyroid associated ophthalmopathy

甲状腺相关性眼病(TAO),是一种与自身免疫性甲状腺病相关的器官特异性自身免疫性疾病。目前,TAO的发病机制尚未完全明确,但已发现氧化应激反应对TAO的发生与发展具有重要影响。炎症和氧化应激恶性循环、酶促抗氧化系统耗竭及多种环境因素作用可诱发TAO的氧化应激反应,促进眼眶成纤维细胞增殖和炎症介质表达。而给予TAO患者硒制剂等抗氧化剂治疗,可以通过抑制氧化应激反应达到改善临床症状的目的。本文中笔者就TAO氧化应激反应的病理改变、发生机制和抗氧化治疗方面的研究现状进行综述。

Thyroid associated ophthalmopathy(TAO)is an organ specific autoimmune disease associated with autoimmune thyroid disease.Currently,the pathogenesis of TAO has not been completely determined,but oxidative stress has been found to have an important impact on the occurrence and development of TAO.The vicious cycle of inflammation and oxidative stress,the depletion of enzymatic antioxidant system and various environmental factors could induce the oxidative stress response of TAO,promote the proliferation of orbital fibroblasts and the expression of inflammatory mediators.The treatment of TAO patients with selenium and other antioxidants could improve the clinical symptoms by inhibiting oxidative stress.In this paper,the pathological changes,pathogenesis and antioxidant treatment of oxidative stress for TAO patients were reviewed.