儿童频繁夜间遗尿症与出生窒息的相关性研究

Correlation between frequent nocturnal enuresis and birth asphyxia in children

目的分析频繁夜间遗尿症与出生窒息的关系,为频繁夜间遗尿症的病因研究提供实证依据。方法于2014年6月-2015年6月按照分层整群随机抽样方法在上海市区3个区(静安、徐汇和杨浦)和郊区4个区(闵行、浦东、奉贤和崇明)选取62290名5~12岁儿童为研究对象。采用多因素Logistic回归分析频繁夜间遗尿症与出生窒息的关系。结果上海市5~12岁儿童频繁夜间遗尿症的发病率为0.5%(327/62290)。单因素Logistic回归分析显示频繁夜间遗尿症与出生窒息显著相关(OR=4.127,95%CI:2.994~5.690),多因素Logistic回归分析显示存在出生窒息的儿童仍具有患频繁夜间遗尿症的高风险(OR=3.001,95%CI:2.054~4.385,P<0.001),此外,还得出两者的相关性在男童中(OR=3.518,95%CI:2.275~5.438,P<0.001)比女童(OR=2.293,95%CI:1.041~5.051,P=0.039)更显著。结论频繁夜间遗尿症与出生窒息显著相关,并且此相关性在男童中更高,提示出生窒息为频繁夜间遗尿的高危因素之一。

Objective To explore the correlation between frequent nocturnal enuresis and birth asphyxia,in order to provide empirical evidence for clinical analysis of the etiology of frequent nocturnal enuresis.Methods A total of 62290 children aged 5-12 years were selected in this study in Shanghai from June 2014 to June 2015 by a stratified cluster random sampling method.The correlation between frequent nocturnal enuresis and birth asphyxia was analyzed by multivariate Logistic regression.Results The incidence of frequent nocturnal enuresis in children aged 5-12 years was 0.5%(327/62290).Univariate Logistic regression analysis showed that frequent nocturnal enuresis was significantly correlated with birth asphyxia(OR=4.127,95%CI:2.994-5.690,P<0.001).Multivariate Logistic regression analysis indicated that children with birth asphyxia still had a high risk of developing frequent nocturnal enuresis(OR=3.001,95%CI=2.054—4.385,P<0.001).In addition,the correlation between frequent nocturnal enuresis and birth asphyxia was closer in boys(OR=3.518,95%CI:2.275—5.438,P<0.001)than that in girls(OR=2.293,95%CI:1.041—5.051,P=0.039).Conclusion Frequent nocturnal enuresis is significantly associated with birth asphyxia,and the correlation is more closer in boys,indicating that birth asphyxia is a high risk factor for frequent nocturnal enuresis.