艰难类梭菌芽胞形成和萌发相关调控的研究进展

Advances in regulation of Clostridioides difficile sporulation and germination

艰难类梭菌(Clostridioides difficile)是一种革兰氏阳性、可产毒素的专性厌氧菌,是引起抗生素相关性腹泻的主要致病菌。芽胞是造成艰难类梭菌传播和感染复发的重要因素,其形成和萌发在感染的发展过程中起到重要作用。近年来,越来越多的艰难类梭菌芽胞形成和萌发的具体机制被阐明。本文就近年来艰难类梭菌芽胞形成和萌发的相关分子调控机制的研究进展进行综述,以期为开发针对芽胞的有效治疗手段提供思路。

Clostridioides difficile is a Gram-positive, toxin-producing obligate anaerobic bacterium, which is the main pathogen causing antibiotic-associated diarrhea. Spore is an important factor causing spread of C. difficile and infection recurrence. Sporulation and germination of C. difficile play an important role in the development of infection. In recent years, more and more specific mechanisms of C. difficile spore formation and germination have been elucidated. In this article, we reviewed the recent research progress on the molecular regulation mechanisms of C. difficile sporulation and germination to provide ideas for the development of effective treatments targeting spores.